Strain Data Sheet

RBRC03340

Strain Information

Image
BRC No.RBRC03340
Type
SpeciesMus musculus
Strain nameRae28 KO
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.
Y Takihara, D Tomotsune, M Shirai, Y Katoh-Fukui, K Nishii, M A Motaleb, M Nomura, R Tsuchiya, Y Fujita, Y Shibata, T Higashinakagawa, K Shimada
Development, 124(19): 3673-3682 (1997). 9367423

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NamePromoterDiseases Related to This Gene

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal B cell differentiation(MP:0002144)

  • abnormal bulbus cordis morphology(MP:0010568)

  • abnormal cardiac outflow tract development(MP:0006126)

  • abnormal cardiovascular development(MP:0002925)

  • abnormal cardiovascular system morphology(MP:0002127)
    • more 34 phenotypes
  • abnormal heart looping(MP:0000269)

  • abnormal heart morphology(MP:0000266)

  • abnormal heart right ventricle outflow tract morphology(MP:0010428)

  • abnormal hematopoietic stem cell morphology(MP:0004808)

  • abnormal occipital bone morphology(MP:0005269)

  • abnormal optic cup morphology(MP:0004269)

  • abnormal presphenoid bone morphology(MP:0004448)

  • abnormal semilunar valve morphology(MP:0002746)

  • abnormal sphenoid bone morphology(MP:0000104)

  • abnormal sternum morphology(MP:0000157)

  • abnormal vertebrae morphology(MP:0000137)

  • aortic valve stenosis(MP:0006117)

  • bilateral cleft palate(MP:0021210)

  • cervical vertebral fusion(MP:0004620)

  • cervical vertebral transformation(MP:0004615)

  • cleft hard palate(MP:0013545)

  • cleft secondary palate(MP:0009890)

  • decreased body size(MP:0001265)

  • decreased spleen weight(MP:0004953)

  • decreased thymus weight(MP:0004956)

  • dilated heart ventricle(MP:0008022)

  • extramedullary hematopoiesis(MP:0000240)

  • heart right ventricle hypertrophy(MP:0000276)

  • impaired hematopoiesis(MP:0001606)

  • lumbar vertebral transformation(MP:0004616)

  • overriding aortic valve(MP:0000273)

  • palatal shelves fail to meet at midline(MP:0009888)

  • parathyroid hypoplasia(MP:0003494)

  • perinatal lethality, complete penetrance(MP:0011089)

  • pulmonary trunk hypoplasia(MP:0010458)

  • pulmonary valve stenosis(MP:0006128)

  • small occipital bone(MP:0004441)

  • thin ventricular wall(MP:0000280)

  • ventricular septal defect(MP:0010402)
    • Detailed phenotype data

    Ordering Information

    Donor DNARae28 genomic DNA (mouse), Neomycin resistance gene (E. coli)
    Research application
    Specific Term and ConditionsThe BIOLOGICAL RESOURCE shall be used only for academic research purposes by a non-profit organization.
    The RECIPIENT of a non-profit organization must prior contact RIKEN BRC and negotiate with Mitsubishi Chemical Corporation to use the BIOLOGICAL RESOURCE for purposes of other than academic research.
    In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE in relevant journals and meetings, the RECIPIENT must stipulate the source of the BIOLOGICAL RESOURCE and an acknowledgment to Mitsubishi Chemical Corporation.
    The RECIPIENT agrees that RIKEN BRC informs annually to Mitsubishi Chemical Corporation of RECIPIENT organization, RECIPIENT name, the specific research purpose and the date of distribution.
    DepositorYoshihiro Takihara (Mitsubishi Kasei Institute of Life Sciences)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data