Strain Data Sheet

RBRC03338

Strain Information

Image
BRC No.RBRC03338
Type
SpeciesMus musculus
Strain nameC57BL/6N-Ttll9<tm1Seto>/SetoRbrc
Former Common nameTL9 KO (B6N)
H-2 Haplotype
ES Cell line
Background strainC57BL/6NJcl
Appearance
Strain developmentDeveloped by Koji Ikegami and Mitsutoshi Setou, Mitsubishi Kagaku Institute of Life Sciences. C57BL/6N derived ES cells were used. The mice were crossed to C57BL/6N.
Strain descriptionTtll9 (TL9) gene knockout mice. Exons 4 and 5 were replaced with neo cassette. A region including an initiation site of TTL domain was removed. Initiation codon is in exon 1. Null type mutant. Homozygous mutant male mice are infertile.
Colony maintenanceHeterozygote x Wild-type [C57BL/6NJcl]
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NamePromoterDiseases Related to This Gene
Ttll9
tubulin tyrosine ligase-like family, member 92
Ttll9<tm1Seto>
targeted mutation 1, Mitsutoshi Setou

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal sperm axoneme morphology(MP:0009838)

  • abnormal sperm fibrous sheath morphology(MP:0030590)

  • abnormal sperm physiology(MP:0004543)

  • abnormal sperm principal piece morphology(MP:0009836)

  • abnormal testis physiology(MP:0004884)
    • more 7 phenotypes
  • asthenozoospermia(MP:0002675)

  • decreased sperm progressive motility(MP:0020451)

  • detached sperm flagellum(MP:0008893)

  • male infertility(MP:0001925)

  • nervous system phenotype(MP:0003631)

  • oligozoospermia(MP:0002687)

  • teratozoospermia(MP:0005578)
    • Detailed phenotype data

    Ordering Information

    Donor DNATtll9 genomic DNA (mouse), neo (E. coli)
    Research application
    Specific Term and ConditionsThe BIOLOGICAL RESOURCE shall be used only for academic research purposes by a non-profit organization.
    The RECIPIENT of a non-profit organization must prior contact RIKEN BRC and negotiate with Mitsubishi Chemical Corporation to use the BIOLOGICAL RESOURCE for purposes of other than academic research.
    In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE in relevant journals and meetings, the RECIPIENT must stipulate the source of the BIOLOGICAL RESOURCE and an acknowledgment to Mitsubishi Chemical Corporation.
    The RECIPIENT agrees that RIKEN BRC informs annually to Mitsubishi Chemical Corporation of RECIPIENT organization, RECIPIENT name, the specific research purpose and the date of distribution.
    DepositorMitsutoshi Setou (Mitsubishi Kasei Institute of Life Sciences)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data