Strain Data Sheet

RBRC03117

Strain Information

Image
BRC No.RBRC03117
TypeGene TrapCartagena
SpeciesMus musculus
Strain nameB6.129S1-Tcfcp2l1<Gt(pLSABetageo)1Sjt>
Former Common nameTcfcp211trap
H-2 Haplotype
ES Cell lineCJ7 [129S1/SvImJ]
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Yoshifumi Yamaguchi and Shinji Takada, Okazaki Institute for Integrative Bioscience in 2005. CJ7 (129S1/Sv-Oca2<+> Tyr<+> Kitl<+>) ES cells derived. The mutant mice were backcrossed to C57BL/6J over 11 times.
Strain descriptionTcfcp2l1 gene trapped mice. The pLSABetageo vector was inserted in the second intron of Tcfcp2l1 gene. Homozygous mutant mice show a partial postnatal lethality.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
References
Gene trap screening as an effective approach for identification of Wnt-responsive genes in the mouse embryo.
Yamaguchi Y, Ogura S, Ishida M, Karasawa M, Takada S
Dev. Dyn., 233, 484-495 (2005). 15778975

Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse.
Yamaguchi Y, Yonemura S, Takada S
Development, 133, 4737-4748 (2006). 17079272

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tcfcp211
MGI:2444691		transcription factor CP2-like 11Tcfcp211<Gt(pLSABetageo)1Sjt>
MGI:3707684		gene trap 1, shinji Takada
lacZ beta-galactosidase (E. coli)1
neo neomycin resistance gene (E. coli)1

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal distal convoluted tubule morphology(MP:0004757)

  • abnormal gland morphology(MP:0002163)

  • abnormal kidney collecting duct intercalated cell morphology(MP:0011754)

  • abnormal kidney morphology(MP:0002135)

  • abnormal nasal gland morphology(MP:0013580)
    • more 12 phenotypes
  • abnormal renal tubule morphology(MP:0002703)

  • abnormal salivary gland physiology(MP:0005310)

  • abnormal submandibular gland morphology(MP:0003793)

  • abnormal ureter morphology(MP:0000534)

  • dilated renal tubule(MP:0002705)

  • increased urine chloride ion level(MP:0011459)

  • increased urine potassium level(MP:0005619)

  • increased urine sodium level(MP:0006316)

  • polyuria(MP:0001762)

  • postnatal growth retardation(MP:0001732)

  • postnatal lethality, incomplete penetrance(MP:0011086)

  • renal hypoplasia(MP:0003446)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Tcfcp2l1 genomic DNA, pSAβgeo
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Dyn., 233, 484-495 (2005). Development,133, 4737-4348 (2006). The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorShinji Takada (National Institute for Basic Biology)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data