Strain Data Sheet

Trojani MC, Nollet M, Camuzard O, Santucci-Darmanin S, Breuil V, Burel-Vandenbos F, Fradet L, Le Gall M, Salnot V, Heymann D, Carle GF, Pierrefite-Carle V.
Atg5/Autophagy inactivation in mouse bone microenvironment promotes tumor development.
Autophagy (2026) 41612597

Tian X, Wu B, Yang K, Wang Y, Li Y, Guan J, Wang K, Zhao Y, Sun K, Ling Y, Zheng J, Xie M, Liu W, Ye X, Li C, Jiang L, Zhao M.
Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis.
Cell Stem Cell 33(7) 1205-1222.e11(2026) 42392052

Keary KM 3rd, Sojka E, Gonzalez M, Li Z.
Autophagy Impacts Dendritic Spines Differently in Proximal and Distal Dendrites of Hippocampus CA1 Neurons.
Hippocampus 36(1) e70069(2026) 41546430

Davanzo GG, Ribeiro G, Dos-Santos D, Berçot MR, Zaidan I, Menezes Dos Reis L, Virgilio-da-Silva JV, Castelucci BG, Estevão P, Souza WD, Bruneta HS, Fachi JL, Costa WL, Andrade JNB, Profeta GS, Dias RR, Wassano NS, de Brito Monteiro L, Aparecida da Silva Pereira J, Favero de Aguiar C, Cruz Angelim MKS, Santos WG, Carregari VC, Peña J, de Carvalho Fraga CA, Mori MA, Consonni SR, Martins-de-Souza D, Vinolo MAR, Nakaya H, Murray PJ, Beheshti A, Cunha LD, Moraes-Vieira PM.
Temporal control of macrophage pro-inflammatory phenotype by a biphasic HIF-1α regulatory program.
Mol Cell (2026) 42480523

Mearns H, Long JS, Lilla S, Hodge K, Ladds MJGW, Nixon C, Fernández-Palanca P, Zanivan S, Acedo P, Pereira SP, Ryan KM.
Identification of serum protein biomarkers for pre-cancerous lesions associated with pancreatic ductal adenocarcinoma.
Mol Oncol (2026) 41709591

Makareeva E, Omari S, Roberts-Pilgrim AM, Gorrell L, Radant B, Sellamani M, Mertz EL, Khoury B, Kozloff K, Leikin S.
LC3 and GABARAP independent autophagy of misfolded procollagen in mouse osteoblasts.
Autophagy 21(12) 2932-2947(2025) 40851209

Gao Y, Chen S, Jiao S, Fan Y, Li X, Tan N, Fang J, Xu L, Huang Y, Zhao J, Guo S, Liu T, Xu W.
ATG5-regulated CCL2/MCP-1 production in myeloid cells selectively modulates anti-malarial CD4+ Th1 responses.
Autophagy 20(6) 1398-1417(2024) 38368631

Gong Y, Zhu W, Li Y, Lu T, Tan J, He C, Yang L, Zhu Y, Gong L.
Dynamic regulation of proximal tubular autophagy from injury to repair after ischemic kidney damage.
Cell Mol Biol Lett 29(1) 151(2024) 39639205

Oravecz-Wilson K, Lauder E, Taylor A, Maneix L, Van Nostrand JL, Sun Y, Li L, Zhao D, Liu C, Reddy P.
Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.
J Clin Invest 134(5) (2024) 38426503

Sun F, Ali NN, Londoño-Vásquez D, Simintiras CA, Qiao H, Ortega MS, Agca Y, Takahashi M, Rivera RM, Kelleher AM, Sutovsky P, Patterson AL, Balboula AZ.
Increased DNA damage in full-grown oocytes is correlated with diminished autophagy activation.
Nat Commun 15(1) 9463(2024) 39487138

Keary KM 3rd, Gu QH, Chen J, Li Z.
Dendritic distribution of autophagosomes underlies pathway-selective induction of LTD.
Cell Rep 42(8) 112898(2023) 37516958

Yi-Qun Zhang, Ta Xiao, Chang-Jun Song, Yang-Ying Ke, Xiang Gao, Min Li, Heng Gu, Xu Chen
Deficiency of Autophagy-Related Gene 5 in Keratinocytes Leads to Aggravation of Epidermal Damage in 2,4-dinitrochlorobenzene-induced Allergic Contact Dermatitis
International Journal of Dermatology and Venereology (2023)

Mitsui K, Hishiyama S, Jain A, Kotoda Y, Abe M, Matsukawa T, Kotoda M.
Role of macrophage autophagy in postoperative pain and inflammation in mice.
J Neuroinflammation 20(1) 102(2023) 37131209

Minami Y, Hoshino A, Higuchi Y, Hamaguchi M, Kaneko Y, Kirita Y, Taminishi S, Nishiji T, Taruno A, Fukui M, Arany Z, Matoba S.
Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion.
Nat Commun 14(1) 4084(2023) 37443159

Cheng J, Wang Y, Yin L, Liang W, Zhang J, Ma C, Zhang Y, Liu B, Wang J, Zhao W, Li M, Wei L.
The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells.
mBio e0148023(2023) 37909764

Suzuki Y, Aono Y, Akiyama N, Horiike Y, Naoi H, Horiguchi R, Shibata K, Hozumi H, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T.
Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma.
Autophagy 18(9) 2216-2228(2022) 35098856

Yu S, Wang H, Liu M, Pei F, Liu H, Zhang J, Zhang L, Li Q, Chen Z.
Loss of ATG5 in KRT14+ cells leads to accumulated functional impairments of salivary glands via pyroptosis.
FASEB J 36(12) e22631(2022) 36342387

Lee TY, Lu WJ, Changou CA, Hsiung YC, Trang NTT, Lee CY, Chang TH, Jayakumar T, Hsieh CY, Yang CH, Chang CC, Chen RJ, Sheu JR, Lin KH.
Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism.
Autophagy 17(12) 4141-4158(2021) 33749503

Vujić N, Bradić I, Goeritzer M, Kuentzel KB, Rainer S, Kratky D, Radović B.
ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages.
Autophagy 17(11) 3402-3407(2021) 33459130

Wang F, He Q, Gao Z, Redington AN.
Atg5 knockdown induces age-dependent cardiomyopathy which can be rescued by repeated remote ischemic conditioning.
Basic Res Cardiol 116(1) 47(2021) 34319513

Gu Q, Jiao S, Duan K, Wang YX, Petralia RS, Li Z.
The BAD-BAX-Caspase-3 Cascade Modulates Synaptic Vesicle Pools via Autophagy.
J Neurosci 41(6) 1174-1190(2021) 33303681

Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V.
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Neuron 109(2) 299-313.e9(2021) 33157003

Sekiguchi K, Miyahara H, Inoue M, Kiyota K, Sakai K, Hanada T, Ihara K.
Metabolome Characteristics of Liver Autophagy Deficiency under Starvation Conditions in Infancy.
Nutrients 13(9) (2021) 34578904

Shen H, Zhu H, Panja D, Gu Q, Li Z.
Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling.
Nat Commun 11(1) 2979(2020) 32532981

Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S, Furlanis E, Gomez AM, Hoshina N, Huang WH, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, Maruo T, Motohashi J, Pai EL, Pelkey KA, Pereira A, Philips T, Sinclair JL, Stogsdill JA, Traunmüller L, Wang J, Wortel J, You W, Abumaria N, Beier KT, Brose N, Burgess HA, Cepko CL, Cloutier JF, Eroglu C, Goebbels S, Kaeser PS, Kay JN, Lu W, Luo L, Mandai K, McBain CJ, Nave KA, Prado MAM, Prado VF, Rothstein J, Rubenstein JLR, Saher G, Sakimura K, Sanes JR, Scheiffele P, Takai Y, Umemori H, Verhage M, Yuzaki M, Zoghbi HY, Kawabe H, Craig AM.
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.
Neuron 106(1) 37-65.e5(2020) 32027825

Li X, Wu J, Sun X, Wu Q, Li Y, Li K, Zhang Q, Li Y, Abel ED, Chen H.
Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury.
Stem Cell Reports 14(3) 420-432(2020) 32059792

Peng X, Wang Y, Li H, Fan J, Shen J, Yu X, Zhou Y, Mao H.
ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury.
Cell Death Dis 10(4) 253(2019) 30874544

Li K, Li M, Li W, Yu H, Sun X, Zhang Q, Li Y, Li X, Li Y, Abel ED, Wu Q, Chen H.
Airway epithelial regeneration requires autophagy and glucose metabolism.
Cell Death Dis 10(12) 875(2019) 31748541

Kurashige T, Nakajima Y, Shimamura M, Matsuyama M, Yamada M, Nakashima M, Nagayama Y.
Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice.
Endocrinology 160(9) 2085-2092(2019) 31314096

Bankston AN, Forston MD, Howard RM, Andres KR, Smith AE, Ohri SS, Bates ML, Bunge MB, Whittemore SR.
Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination.
Glia 67(9) 1745-1759(2019) 31162728

Chai Q, Wang X, Qiang L, Zhang Y, Ge P, Lu Z, Zhong Y, Li B, Wang J, Zhang L, Zhou D, Li W, Dong W, Pang Y, Gao GF, Liu CH.
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy.
Nat Commun 10(1) 1973(2019) 31036822

Abernathy E, Mateo R, Majzoub K, van Buuren N, Bird SW, Carette JE, Kirkegaard K.
Differential and convergent utilization of autophagy components by positive-strand RNA viruses.
PLoS Biol 17(1) e2006926(2019) 30608919

Shroff A, Sequeira R, Patel V, Reddy KVR.
Knockout of autophagy gene, ATG5 in mice vaginal cells abrogates cytokine response and pathogen clearance during vaginal infection of Candida albicans.
Cell Immunol 324 59-73(2018) 29306553

Alissafi T, Hatzioannou A, Mintzas K, Barouni RM, Banos A, Sormendi S, Polyzos A, Xilouri M, Wielockx B, Gogas H, Verginis P.
Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells.
J Clin Invest 128(9) 3840-3852(2018) 29920188

Shen L, Yang Y, Ou T, Key CC, Tong SH, Sequeira RC, Nelson JM, Nie Y, Wang Z, Boudyguina E, Shewale SV, Zhu X.
Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy.
J Lipid Res 58(9) 1808-1821(2017) 28729463

Zhang Y, Cross SD, Stanton JB, Marmorstein AD, Le YZ, Marmorstein LY.
Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7.
Mol Vis 23 228-241(2017) 28465655

Kononenko NL, Claßen GA, Kuijpers M, Puchkov D, Maritzen T, Tempes A, Malik AR, Skalecka A, Bera S, Jaworski J, Haucke V.
Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration.
Nat Commun 8 14819(2017) 28387218

Liu Q, Chen L, Atkinson JM, Claxton DF, Wang HG.
Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model.
Cell Death Dis 7(9) e2361(2016) 27607576

Akoumianaki T, Kyrmizi I, Valsecchi I, Gresnigt MS, Samonis G, Drakos E, Boumpas D, Muszkieta L, Prevost MC, Kontoyiannis DP, Chavakis T, Netea MG, van de Veerdonk FL, Brakhage AA, El-Benna J, Beauvais A, Latge JP, Chamilos G.
Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity.
Cell Host Microbe 19(1) 79-90(2016) 26749442

Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F.
Cardioprotection and lifespan extension by the natural polyamine spermidine.
Nat Med 22(12) 1428-1438(2016) 27841876

Camuzard O, Santucci-Darmanin S, Breuil V, Cros C, Gritsaenko T, Pagnotta S, Cailleteau L, Battaglia S, Panaïa-Ferrari P, Heymann D, Carle GF, Pierrefite-Carle V.
Sex-specific autophagy modulation in osteoblastic lineage: a critical function to counteract bone loss in female.
Oncotarget 7(41) 66416-66428(2016) 27634908

Lu Q, Yao Y, Hu Z, Hu C, Song Q, Ye J, Xu C, Wang AZ, Chen Q, Wang QK.
Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease.
PLoS Biol 14(8) e1002529(2016) 27513923

Jessop F, Hamilton RF, Rhoderick JF, Shaw PK, Holian A.
Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure.
Toxicol Appl Pharmacol 309 101-10(2016) 27594529

Newton PT, Vuppalapati KK, Bouderlique T, Chagin AS.
Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner.
Autophagy 11(9) 1594-607(2015) 26259639

Li F, Han X, Li F, Wang R, Wang H, Gao Y, Wang X, Fang Z, Zhang W, Yao S, Tong X, Wang Y, Feng Y, Sun Y, Li Y, Wong KK, Zhai Q, Chen H, Ji H.
LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response.
Cancer Cell 27(5) 698-711(2015) 25936644

Tang AH, Rando TA.
Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation.
EMBO J 33(23) 2782-97(2014) 25316028

Torisu T, Torisu K, Lee IH, Liu J, Malide D, Combs CA, Wu XS, Rovira II, Fergusson MM, Weigert R, Connelly PS, Daniels MP, Komatsu M, Cao L, Finkel T.
Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor.
Nat Med 19(10) 1281-7(2013) 24056772

Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, Adams PD, Anderson KI, Gottlieb E, Sansom OJ, Ryan KM.
p53 status determines the role of autophagy in pancreatic tumour development.
Nature 504(7479) 296-300(2013) 24305049

Ni HM, Boggess N, McGill MR, Lebofsky M, Borude P, Apte U, Jaeschke H, Ding WX.
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
Toxicol Sci 127(2) 438-50(2012) 22491424

Mizushima N, Yoshimori T, Levine B.
Methods in mammalian autophagy research.
Cell 140(3) 313-26(2010) 20144757