Strain Data Sheet

Suzuki Y, Aono Y, Akiyama N, Horiike Y, Naoi H, Horiguchi R, Shibata K, Hozumi H, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T.
Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma.
Autophagy 18(9) 2216-2228(2022) 35098856

Lee TY, Lu WJ, Changou CA, Hsiung YC, Trang NTT, Lee CY, Chang TH, Jayakumar T, Hsieh CY, Yang CH, Chang CC, Chen RJ, Sheu JR, Lin KH.
Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism.
Autophagy 17(12) 4141-4158(2021) 33749503

Mizushima N, Yoshimori T, Levine B.
Methods in mammalian autophagy research.
Cell 140(3) 313-26(2010) 20144757

Peng X, Wang Y, Li H, Fan J, Shen J, Yu X, Zhou Y, Mao H.
ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury.
Cell Death Dis 10(4) 253(2019) 30874544

Li K, Li M, Li W, Yu H, Sun X, Zhang Q, Li Y, Li X, Li Y, Abel ED, Wu Q, Chen H.
Airway epithelial regeneration requires autophagy and glucose metabolism.
Cell Death Dis 10(12) 875(2019) 31748541

Akoumianaki T, Kyrmizi I, Valsecchi I, Gresnigt MS, Samonis G, Drakos E, Boumpas D, Muszkieta L, Prevost MC, Kontoyiannis DP, Chavakis T, Netea MG, van de Veerdonk FL, Brakhage AA, El-Benna J, Beauvais A, Latge JP, Chamilos G.
Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity.
Cell Host Microbe 19(1) 79-90(2016) 26749442

Shroff A, Sequeira R, Patel V, Reddy KVR.
Knockout of autophagy gene, ATG5 in mice vaginal cells abrogates cytokine response and pathogen clearance during vaginal infection of Candida albicans.
Cell Immunol 324 59-73(2018) 29306553

Tang AH, Rando TA.
Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation.
EMBO J 33(23) 2782-97(2014) 25316028

Kurashige T, Nakajima Y, Shimamura M, Matsuyama M, Yamada M, Nakashima M, Nagayama Y.
Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice.
Endocrinology 160(9) 2085-2092(2019) 31314096

Yu S, Wang H, Liu M, Pei F, Liu H, Zhang J, Zhang L, Li Q, Chen Z.
Loss of ATG5 in KRT14+ cells leads to accumulated functional impairments of salivary glands via pyroptosis.
FASEB J 36(12) e22631(2022) 36342387

Bankston AN, Forston MD, Howard RM, Andres KR, Smith AE, Ohri SS, Bates ML, Bunge MB, Whittemore SR.
Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination.
Glia 67(9) 1745-1759(2019) 31162728

Yi-Qun Zhang, Ta Xiao, Chang-Jun Song, Yang-Ying Ke, Xiang Gao, Min Li, Heng Gu, Xu Chen
Deficiency of Autophagy-Related Gene 5 in Keratinocytes Leads to Aggravation of Epidermal Damage in 2,4-dinitrochlorobenzene-induced Allergic Contact Dermatitis
International Journal of Dermatology and Venereology Publish Ahead of Print (2023)

Alissafi T, Hatzioannou A, Mintzas K, Barouni RM, Banos A, Sormendi S, Polyzos A, Xilouri M, Wielockx B, Gogas H, Verginis P.
Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells.
J Clin Invest 128(9) 3840-3852(2018) 29920188

Shen L, Yang Y, Ou T, Key CC, Tong SH, Sequeira RC, Nelson JM, Nie Y, Wang Z, Boudyguina E, Shewale SV, Zhu X.
Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy.
J Lipid Res 58(9) 1808-1821(2017) 28729463

Mitsui K, Hishiyama S, Jain A, Kotoda Y, Abe M, Matsukawa T, Kotoda M.
Role of macrophage autophagy in postoperative pain and inflammation in mice.
J Neuroinflammation 20(1) 102(2023) 37131209

Zhang Y, Cross SD, Stanton JB, Marmorstein AD, Le YZ, Marmorstein LY.
Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7.
Mol Vis 23 228-241(2017) 28465655

Minami Y, Hoshino A, Higuchi Y, Hamaguchi M, Kaneko Y, Kirita Y, Taminishi S, Nishiji T, Taruno A, Fukui M, Arany Z, Matoba S.
Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion.
Nat Commun 14(1) 4084(2023) 37443159

Shen H, Zhu H, Panja D, Gu Q, Li Z.
Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling.
Nat Commun 11(1) 2979(2020) 32532981

Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F.
Cardioprotection and lifespan extension by the natural polyamine spermidine.
Nat Med 22(12) 1428-1438(2016) 27841876

Torisu T, Torisu K, Lee IH, Liu J, Malide D, Combs CA, Wu XS, Rovira II, Fergusson MM, Weigert R, Connelly PS, Daniels MP, Komatsu M, Cao L, Finkel T.
Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor.
Nat Med 19(10) 1281-7(2013) 24056772

Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, Adams PD, Anderson KI, Gottlieb E, Sansom OJ, Ryan KM.
p53 status determines the role of autophagy in pancreatic tumour development.
Nature 504(7479) 296-300(2013) 24305049

Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V.
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Neuron 109(2) 299-313.e9(2021) 33157003

Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S, Furlanis E, Gomez AM, Hoshina N, Huang WH, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, Maruo T, Motohashi J, Pai EL, Pelkey KA, Pereira A, Philips T, Sinclair JL, Stogsdill JA, Traunmüller L, Wang J, Wortel J, You W, Abumaria N, Beier KT, Brose N, Burgess HA, Cepko CL, Cloutier JF, Eroglu C, Goebbels S, Kaeser PS, Kay JN, Lu W, Luo L, Mandai K, McBain CJ, Nave KA, Prado MAM, Prado VF, Rothstein J, Rubenstein JLR, Saher G, Sakimura K, Sanes JR, Scheiffele P, Takai Y, Umemori H, Verhage M, Yuzaki M, Zoghbi HY, Kawabe H, Craig AM.
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.
Neuron 106(1) 37-65.e5(2020) 32027825

Sekiguchi K, Miyahara H, Inoue M, Kiyota K, Sakai K, Hanada T, Ihara K.
Metabolome Characteristics of Liver Autophagy Deficiency under Starvation Conditions in Infancy.
Nutrients 13(9) (2021) 34578904

Abernathy E, Mateo R, Majzoub K, van Buuren N, Bird SW, Carette JE, Kirkegaard K.
Differential and convergent utilization of autophagy components by positive-strand RNA viruses.
PLoS Biol 17(1) e2006926(2019) 30608919

Li X, Wu J, Sun X, Wu Q, Li Y, Li K, Zhang Q, Li Y, Abel ED, Chen H.
Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury.
Stem Cell Reports 14(3) 420-432(2020) 32059792

Jessop F, Hamilton RF, Rhoderick JF, Shaw PK, Holian A.
Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure.
Toxicol Appl Pharmacol 309 101-10(2016) 27594529

Ni HM, Boggess N, McGill MR, Lebofsky M, Borude P, Apte U, Jaeschke H, Ding WX.
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
Toxicol Sci 127(2) 438-50(2012) 22491424

Cheng J, Wang Y, Yin L, Liang W, Zhang J, Ma C, Zhang Y, Liu B, Wang J, Zhao W, Li M, Wei L.
The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells.
mBio e0148023(2023) 37909764