Strain Data Sheet

RBRC02844

Strain Information

Image
BRC No.RBRC02844
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S4-Efp<tm1Mura>
Former Common nameEfp Knockout mouse、B6.129S4-Efp<tm1Mura>
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.
Urano T, Saito T, Tsukui T, Fujita M, Hosoi T, Muramatsu M, Ouchi Y, Inoue S
Nature, 417, 871-875 (2002). 12075357

Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor alpha.
Orimo A, Inoue S, Minowa O, Tominaga N, Tomioka Y, Sato M, Kuno J, Hiroi H, Shimizu Y, Suzuki M, Noda T, Muramatsu M
Proc. Natl. Acad. Sci. USA, 96, 12027-12032 (1999). 10518570

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
Gack M U, Shin Y C, Joo C H, Urano T, Liang C, Sun L, Takeuchi O, Akira S, Chen Z, Inoue S, Jung J U
Nature, 446, 916-920 (2007). 17392790

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Trim25tripartite motif-containing 2511Trim25targeted mutation 1, Masami Muramatsu
neoneomycin resistance gene (E. coli)11mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • decreased susceptibility to parasitic infection induced morbidity/mortality(MP:0010751)

  • decreased susceptibility to parasitic infection(MP:0005026)

  • small uterus(MP:0002637)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter, E. coli Neomycin resistance gene, mouse phosphoglycerate kinase polyA signal, mouse Trim25 genomic DNA
    Research applicationCancer Research
    Immunology and Inflammation Research
    Virology Research
    covid19_infection
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 20, 871-875 (2002). Proc. Natl. Acad. Sci. USA, 96, 12027-12032 (1999). The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorSatoshi Inoue (Saitama Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.
    USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.
    Nat Immunol 18(1) 54-63(2017) 27721430