Strain Information | |
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Image | |
BRC No. | RBRC02844 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129S4-Efp<tm1Mura> |
Former Common name | Efp Knockout mouse、B6.129S4-Efp<tm1Mura> |
H-2 Haplotype | |
ES Cell line | J1 [129S4/SvJae] |
Background strain | |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth. Urano T, Saito T, Tsukui T, Fujita M, Hosoi T, Muramatsu M, Ouchi Y, Inoue S Nature, 417, 871-875 (2002). 12075357Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor alpha. Orimo A, Inoue S, Minowa O, Tominaga N, Tomioka Y, Sato M, Kuno J, Hiroi H, Shimizu Y, Suzuki M, Noda T, Muramatsu M Proc. Natl. Acad. Sci. USA, 96, 12027-12032 (1999). 10518570TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Gack M U, Shin Y C, Joo C H, Urano T, Liang C, Sun L, Takeuchi O, Akira S, Chen Z, Inoue S, Jung J U Nature, 446, 916-920 (2007). 17392790 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Trim25 | tripartite motif-containing 25 | 11 | Trim25 | targeted mutation 1, Masami Muramatsu | |||
neo | neomycin resistance gene (E. coli) | 11 | mouse phosphoglycerate kinase promoter (PGK promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse phosphoglycerate kinase promoter, E. coli Neomycin resistance gene, mouse phosphoglycerate kinase polyA signal, mouse Trim25 genomic DNA |
Research application | Cancer Research Immunology and Inflammation Research Virology Research covid19_infection |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 20, 871-875 (2002). Proc. Natl. Acad. Sci. USA, 96, 12027-12032 (1999). The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Satoshi Inoue (Saitama Medical University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P. USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nat Immunol 18(1) 54-63(2017) 27721430 |