Strain Data Sheet

RBRC02796

Strain Information

Image
BRC No.RBRC02796
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Stab2<tm1>
Former Common nameStab2-KO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development2006年樹立TT2 (ES) → CD1(キメラ) → B6 (backcross 7 世代)
Strain description血中ヒアルロン酸濃度が高い。血液学・生化学・組織学的な異常は見られない。
Colony maintenance繁殖効率：Aホモ同士にて維持可能
References
Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis.
Yoshikazu Hirose, Eiko Saijou, Yasuyoshi Sugano, Fumitaka Takeshita, Satoshi Nishimura, Hidenori Nonaka, Yen-Rong Chen, Keisuke Sekine, Taketomo Kido, Takashi Nakamura, Shigeaki Kato, Toru Kanke, Koji Nakamura, Ryozo Nagai, Takahiro Ochiya, Atsushi Miyajima
Proc. Natl. Acad. Sci. USA, 109(11):4263-4268 (2012). 22371575

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Stab2
MGI:2178743		stabilin 210Stab2
MGI:5318244		targeted mutation 1
lacZ beta-galactosidase (E. coli)10
neo neomycin resistance gene (E. coli)10

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal hepatocyte physiology (MP:0010080)

  • decreased metastatic potential (MP:0001273)

  • increased circulating hyaluronic acid level (MP:0014427)
    • Detailed phenotype data

    Ordering Information

    供与核酸PGK promoter (mouse Phosphoglycerate kinase-1 promoter), E. coli lacZ, E. coli neo, mouse Stab2 genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Hematological Research
    提供条件利用者は事前に寄託者の提供承諾書を得る。寄託者の承諾を得る。
    Depositor宮島　篤（国立大学法人東京大学）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    Pirie E, Ray S, Pan C, Fu W, Powers AF, Polikoff D, Miller CM, Kudrna KM, Harris EN, Lusis AJ, Crooke RM, Lee RG.
    Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1.
    PLoS Genet 14(10) e1007732(2018) 30372444
    Donner AJ, Wancewicz EV, Murray HM, Greenlee S, Post N, Bell M, Lima WF, Swayze EE, Seth PP.
    Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver.
    Nucleic Acid Ther 27(4) 209-220(2017) 28448194