Strain Information | |
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Image | |
BRC No. | RBRC02796 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6.Cg-Stab2<tm1> |
Former Common name | Stab2-KO |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | 2006年樹立TT2 (ES) → CD1(キメラ) → B6 (backcross 7 世代) |
Strain description | 血中ヒアルロン酸濃度が高い。血液学・生化学・組織学的な異常は見られない。 |
Colony maintenance | 繁殖効率:Aホモ同士にて維持可能 |
References | Proc. Natl. Acad. Sci. USA, 109(11):4263-4268 (2012). 22371575 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)10 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)10neo; neomycin; |
Ordering Information | |
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供与核酸 | PGK promoter (mouse Phosphoglycerate kinase-1 promoter), E. coli lacZ, E. coli neo, mouse Stab2 genomic DNA |
Research application | Fluorescent Proteins/lacZ System Hematological Research |
提供条件 | 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。 寄託者の承諾を得る。 |
Depositor | 宮島 篤(国立大学法人東京大学) |
Strain Status | 凍結胚 凍結精子 |
Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結精子を1ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Donner AJ, Wancewicz EV, Murray HM, Greenlee S, Post N, Bell M, Lima WF, Swayze EE, Seth PP. Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver. Nucleic Acid Ther 27(4) 209-220(2017) 28448194 Pirie E, Ray S, Pan C, Fu W, Powers AF, Polikoff D, Miller CM, Kudrna KM, Harris EN, Lusis AJ, Crooke RM, Lee RG. Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1. PLoS Genet 14(10) e1007732(2018) 30372444 |