Strain Information | |
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Image | |
BRC No. | RBRC02796 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6.Cg-Stab2<tm1> |
Former Common name | Stab2-KO |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen Y R, Sekine K, Kido T, Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T, Miyajima A Proc. Natl. Acad. Sci. USA, 109(11):4263-4268 (2012). 22371575 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Stab2 | stabilin 2 | 10 | Stab2 | targeted mutation 1 | |||
lacZ | beta-galactosidase (E. coli) | 10 | |||||
neo | neomycin resistance gene (E. coli) | 10 |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | PGK promoter (mouse Phosphoglycerate kinase-1 promoter), E. coli lacZ, E. coli neo, mouse Stab2 genomic DNA |
Research application | Fluorescent Proteins/lacZ System Hematological Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR. |
Depositor | Atsushi Miyajima (The University of Tokyo) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Donner AJ, Wancewicz EV, Murray HM, Greenlee S, Post N, Bell M, Lima WF, Swayze EE, Seth PP. Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver. Nucleic Acid Ther 27(4) 209-220(2017) 28448194 |
Pirie E, Ray S, Pan C, Fu W, Powers AF, Polikoff D, Miller CM, Kudrna KM, Harris EN, Lusis AJ, Crooke RM, Lee RG. Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1. PLoS Genet 14(10) e1007732(2018) 30372444 |