Strain Data Sheet

RBRC02796

Strain Information

Image
BRC No.RBRC02796
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Stab2<tm1>
Former Common nameStab2-KO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis.
Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen Y R, Sekine K, Kido T, Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T, Miyajima A
Proc. Natl. Acad. Sci. USA, 109(11):4263-4268 (2012). 22371575

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Stab2stabilin 210Stab2targeted mutation 1
lacZbeta-galactosidase (E. coli)10
neoneomycin resistance gene (E. coli)10

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal blood homeostasis(MP:0009642)

  • abnormal hepatocyte physiology(MP:0010080)

  • decreased metastatic potential(MP:0001273)
  • Detailed phenotype data

    Ordering Information

    Donor DNAPGK promoter (mouse Phosphoglycerate kinase-1 promoter), E. coli lacZ, E. coli neo, mouse Stab2 genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Hematological Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorAtsushi Miyajima (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    Donner AJ, Wancewicz EV, Murray HM, Greenlee S, Post N, Bell M, Lima WF, Swayze EE, Seth PP.
    Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver.
    Nucleic Acid Ther 27(4) 209-220(2017) 28448194
    Pirie E, Ray S, Pan C, Fu W, Powers AF, Polikoff D, Miller CM, Kudrna KM, Harris EN, Lusis AJ, Crooke RM, Lee RG.
    Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1.
    PLoS Genet 14(10) e1007732(2018) 30372444