Strain Data Sheet

Wentong Wu, Jiangxia Du, Jinjin Li, Shaoyin Zhang, Xingchen Kang, Yashi Cao, Jian Chen, Zengyue Pan, Xiangliang Huang, Zhifei Xu, Bo Yang, Qiaojun He, Xiaochun Yang, Hao Yan, Peihua Luo
Inhibition of Cathepsin B protects against vandetanib-induced hepato-cardiotoxicity by restoring lysosomal damage
International Journal of Biological Sciences 22 1752-1774(2026)

Kang X, Liu W, Ma X, Feng D, Sun H, Wu S.
Dysfunctional autophagy triggers STING1 activation to exacerbate cartilage degeneration in obesity-associated osteoarthritis.
Autophagy 21(12) 3344-3360(2025) 40728163

Han Dong, Yifan Lyu, Chien-Yung Huang, Shih-Yin Tsai
Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle
Autophagy (2025) 39878121

Austin MC, Muralidharan C, Roy S, Crowder JJ, Piganelli JD, Linnemann AK.
Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity.
Front Immunol 16 1504583(2025) 39944686

Chen H, Yang G, Xu DE, Du YT, Zhu C, Hu H, Luo L, Feng L, Huang W, Sun YY, Ma QH.
Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent Manner.
Neurosci Bull 41(3) 374-390(2025) 39283565

Chen H, Sun YY, Li QF, Du YT, Hu NN, Sui AR, Luo XQ, Huang X, Zhu C, Yang G, Yao LL, Tang Y, Hu H, Liu CF, Tao J, Feng L, Kirchhoff F, Huang W, Li S, Ma QH.
Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling.
Sci Adv 11(39) eadq7665(2025) 40991686

Klochkova A, Karami AL, Fuller AD, Parham LR, Panchani SR, Natarajan S, Jackson JL, Mu A, Tan Y, Cai KQ, Klein-Szanto AJ, Muir AB, Tétreault MP, Graña X, Hamilton KE, Whelan KA.
Autophagy Contributes to Homeostasis in Esophageal Epithelium Where High Autophagic Vesicle Level Marks Basal Cells With Limited Proliferation and Enhanced Self-Renewal Potential.
Cell Mol Gastroenterol Hepatol 18(1) 15-40(2024) 38452871

Yuan Y, Yuan L, Yang J, Liu F, Liu S, Li L, Liao G, Tang X, Cheng J, Liu J, Chen Y, Lu Y.
Autophagy-deficient macrophages exacerbate cisplatin-induced mitochondrial dysfunction and kidney injury via miR-195a-5p-SIRT3 axis.
Nat Commun 15(1) 4383(2024) 38782909

Song Y, Na H, Lee SE, Kim YM, Moon J, Nam TW, Ji Y, Jin Y, Park JH, Cho SC, Lee J, Hwang D, Ha SJ, Park HW, Kim JB, Lee HW.
Dysfunctional adipocytes promote tumor progression through YAP/TAZ-dependent cancer-associated adipocyte transformation.
Nat Commun 15(1) 4052(2024) 38744820

Williams PA, Naughton KE, Simon LA, Soto GE, Parham LR, Ma X, Danan CH, Hu W, Friedman ES, McMillan EA, Mehta H, Stoltz MA, Soto Ocaña J, Zackular J, Bittinger K, Whelan KA, Karakasheva TA, Hamilton KE.
Intestinal epithelial autophagy is required for the regenerative benefit of calorie restriction.
Am J Physiol Gastrointest Liver Physiol (2023) 36852920

Yao H, Li J, Liu Z, Ouyang C, Qiu Y, Zheng X, Mu J, Xie Z.
Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression.
Autophagy 19(5) 1491-1511(2023) 36300763

Yan B, Belke D, Gui Y, Chen YX, Jiang ZS, Zheng XL.
Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cells.
Cell Death Discov 9(1) 456(2023) 38097554

Parham LR, Williams PA, Katada K, Nettleford SK, Chatterji P, Acheampong KK, Danan CH, Ma X, Simon LA, Naughton KE, Karakasheva T, McMillan EA, Whelan KA, Brady DC, Shaffer SM, Hamilton KE.
IGF2BP1/IMP1 deletion enhances a facultative stem cell state via regulation of MAP1LC3B.
Cell Mol Gastroenterol Hepatol (2023) 38081361

Oh JE, Kwon S, Byun H, Song H, Lim HJ.
Repopulation of autophagy-deficient stromal cells with autophagy-intact cells after repeated breeding in uterine mesenchyme-specific Atg7 knockout mice.
Clin Exp Reprod Med 50(3) 170-176(2023) 37643830

Chen X, Qin W, Wang L, Jin Y, Tu J, Yuan X.
Autophagy gene Atg7 regulates the development of radiation-induced skin injury and fibrosis of skin.
Skin Res Technol 29(6) e13337(2023) 37357660

Xu Z, Jin Y, Gao Z, Zeng Y, Du J, Yan H, Chen X, Ping L, Lin N, Yang B, He Q, Luo P.
Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib.
Autophagy 18(5) 1152-1173(2022) 34432562

Ni Y, Wu GH, Cai JJ, Zhang R, Zheng Y, Liu JQ, Yang XH, Yang X, Shen Y, Lai JM, Ye XM, Mo SJ.
Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation.
Int J Biol Sci 18(13) 5168-5184(2022) 35982894

Li H, Li X, Xu Z, Lu J, Cao C, You W, Yu Z, Shen H, Chen G.
Unbalanced Regulation of Sec22b and Ykt6 Blocks Autophagosome Axonal Retrograde Flux in Neuronal Ischemia-Reperfusion Injury.
J Neurosci 42(28) 5641-5654(2022) 35654605

Liu H, Lou J, Liu Y, Liu Z, Xie J, Sun J, Pan H, Han W.
Intestinal epithelial cell autophagy deficiency suppresses inflammation-associated colon tumorigenesis.
Mol Ther Nucleic Acids 28 35-46(2022) 35317201

Tan HWS, Lu G, Dong H, Cho YL, Natalia A, Wang L, Chan C, Kappei D, Taneja R, Ling SC, Shao H, Tsai SY, Ding WX, Shen HM.
A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery.
Nat Commun 13(1) 3720(2022) 35764633

Sakai M, Yu Z, Hirayama R, Nakasato M, Kikuchi Y, Ono C, Komatsu H, Nakanishi M, Yoshii H, Stellwagen D, Furuyashiki T, Komatsu M, Tomita H.
Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance.
Neural Plast 2022 7503553(2022) 35222638

Luo P, Yan H, Du J, Chen X, Shao J, Zhang Y, Xu Z, Jin Y, Lin N, Yang B, He Q.
PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1).
Autophagy 17(10) 3221-3237(2021) 33315519

Ando S, Hashida N, Yamashita D, Kawabata T, Asao K, Kawasaki S, Sakurai K, Yoshimori T, Nishida K.
Rubicon regulates A2E-induced autophagy impairment in the retinal pigment epithelium implicated in the pathology of age-related macular degeneration.
Biochem Biophys Res Commun 551 148-154(2021) 33740621

Gu Q, Jiao S, Duan K, Wang YX, Petralia RS, Li Z.
The BAD-BAX-Caspase-3 Cascade Modulates Synaptic Vesicle Pools via Autophagy.
J Neurosci 41(6) 1174-1190(2021) 33303681

Marcelin G, Da Cunha C, Gamblin C, Suffee N, Rouault C, Leclerc A, Lacombe A, Sokolovska N, Gautier EL, Clément K, Dugail I.
Autophagy inhibition blunts PDGFRA adipose progenitors' cell-autonomous fibrogenic response to high-fat diet.
Autophagy 16(12) 2156-2166(2020) 31992125

Wang Y, Liu X, Zhu L, Li W, Li Z, Lu X, Liu J, Hua W, Zhou Y, Gu Y, Zhu M.
PG545 alleviates diabetic retinopathy by promoting retinal Müller cell autophagy to inhibit the inflammatory response.
Biochem Biophys Res Commun 531(4) 452-458(2020) 32800548

Li KC, Wang CH, Zou JJ, Qu C, Wang XL, Tian XS, Liu HW, Cui T.
Loss of Atg7 in Endothelial Cells Enhanced Cutaneous Wound Healing in a Mouse Model.
J Surg Res 249 145-155(2020) 31958599

Luciani A, Schumann A, Berquez M, Chen Z, Nieri D, Failli M, Debaix H, Festa BP, Tokonami N, Raimondi A, Cremonesi A, Carrella D, Forny P, Kölker S, Diomedi Camassei F, Diaz F, Moraes CT, Di Bernardo D, Baumgartner MR, Devuyst O.
Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency.
Nat Commun 11(1) 970(2020) 32080200

Chatterji P, Williams PA, Whelan KA, Samper FC, Andres SF, Simon LA, Parham LR, Mizuno R, Lundsmith ET, Lee DS, Liang S, Wijeratne HS, Marti S, Chau L, Giroux V, Wilkins BJ, Wu GD, Shah P, Tartaglia GG, Hamilton KE.
Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1.
EMBO Rep 20(6) (2019) 31061170

Amersfoort J, Douna H, Schaftenaar FH, Foks AC, Kröner MJ, van Santbrink PJ, van Puijvelde GHM, Bot I, Kuiper J.
Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis.
Front Immunol 9 2937(2018) 30619297

Kang X, Yang W, Feng D, Jin X, Ma Z, Qian Z, Xie T, Li H, Liu J, Wang R, Li F, Li D, Sun H, Wu S.
Cartilage-Specific Autophagy Deficiency Promotes ER Stress and Impairs Chondrogenesis in PERK-ATF4-CHOP-Dependent Manner.
J Bone Miner Res 32(10) 2128-2141(2017) 28304100

Kang X, Yang W, Feng D, Jin X, Ma Z, Qian Z, Xie T, Li H, Liu J, Wang R, Li F, Li D, Sun H, Wu S.
Addendum to "Cartilage-Specific Autophagy Deficiency Promotes ER Stress and Impairs Chondrogenesis in PERK-ATF4-CHOP-Dependent Manner".
J Bone Miner Res 32(10) 2145(2017) 29028133

Zhang Y, Cross SD, Stanton JB, Marmorstein AD, Le YZ, Marmorstein LY.
Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7.
Mol Vis 23 228-241(2017) 28465655

Shang Y, Wang H, Jia P, Zhao H, Liu C, Liu W, Song Z, Xu Z, Yang L, Wang Y, Li W.
Autophagy regulates spermatid differentiation via degradation of PDLIM1.
Autophagy 12(9) 1575-92(2016) 27310465

Muralimanoharan S, Gao X, Weintraub S, Myatt L, Maloyan A.
Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model.
Autophagy 12(5) 752-69(2016) 26986453

Bang S, Lee GK, Shin H, Suh CS, Lim HJ.
Vitrification, in vitro fertilization, and development of Atg7 deficient mouse oocytes.
Clin Exp Reprod Med 43(1) 9-14(2016) 27104152

Li S, Liu C, Gu L, Wang L, Shang Y, Liu Q, Wan J, Shi J, Wang F, Xu Z, Ji G, Li W.
Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36.
Open Biol 6(8) (2016) 27512143

Song ZH, Yu HY, Wang P, Mao GK, Liu WX, Li MN, Wang HN, Shang YL, Liu C, Xu ZL, Sun QY, Li W.
Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice.
Cell Death Dis 6(1) e1589(2015) 25590799

Walter KM, Schönenberger MJ, Trötzmüller M, Horn M, Elsässer HP, Moser AB, Lucas MS, Schwarz T, Gerber PA, Faust PL, Moch H, Köfeler HC, Krek W, Kovacs WJ.
Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy.
Cell Metab 20(5) 882-897(2014) 25440060

Wang H, Wan H, Li X, Liu W, Chen Q, Wang Y, Yang L, Tang H, Zhang X, Duan E, Zhao X, Gao F, Li W.
Atg7 is required for acrosome biogenesis during spermatogenesis in mice.
Cell Res 24(7) 852-69(2014) 24853953

Mizushima N, Yoshimori T, Levine B.
Methods in mammalian autophagy research.
Cell 140(3) 313-26(2010) 20144757