Strain Data Sheet

RBRC02728

Strain Information

Image
BRC No.RBRC02728
TypeTargeted Mutation and Spontaneous MutationCartagena
SpeciesMus musculus
Strain nameMRL.Cg-Fas<lpr> Cd180<tm1Kmiy>
Former Common nameMRL-lpr/lpr RP105-/-, MRL-lpr/lpr Cd180<tm1Kmiy>
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.
Toshihiko Kobayashi, Koichiro Takahashi, Yoshinori Nagai, Takuma Shibata, Masako Otani, Shozo Izui, Shizuo Akira, Yoshiyuki Gotoh, Hiroshi Kiyono, Kensuke Miyake
Int. Immunol., 20, 881-891 (2008). 18492657

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cd180
MGI:1194924		CD180 antigen13Cd180<tm1Kmiy>
MGI:3581654		targeted mutation 1, Kensuke Miyake
neo neomycin resistance gene (E. coli)13 mouse phosphoglycerate kinase promoter (PGK promoter)
Fas
MGI:95484		Fas cell surface death receptor19Fas<lpr>
MGI:1856334		lymphoproliferation
  • autoimmune lymphoproliferative syndrome type 1(DisGeNET, MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal blood urea nitrogen level (MP:0005265)

  • blood vessel inflammation (MP:0001863)

  • decreased B cell number (MP:0005017)

  • decreased CD8-positive, alpha-beta T cell number (MP:0008079)

  • decreased IgG2a level (MP:0008496)
    • more 8 phenotypes
  • decreased IgG3 level (MP:0008498)

  • enlarged lymph nodes (MP:0000702)

  • enlarged spleen (MP:0000691)

  • glomerulonephritis (MP:0002743)

  • hematopoietic system phenotype (MP:0005397)

  • increased anti-nuclear antigen antibody level (MP:0004794)

  • increased autoantibody level (MP:0003725)

  • increased double-negative T cell number (MP:0005090)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E.coli neo, mouse Fas Cd180 genome DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Int. Immunol., 20(7):881-891 (2008).The RECIPIENT must contact the DEPOSITOR in the case of application for any patents use with the results from the use of the BIOLOGICAL RESOURCE.
    DepositorKensuke Miyake (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)

    BRC mice in Publications

    No Data