Strain Data Sheet

RBRC02711

Strain Information

Image
BRC No.RBRC02711
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Osmr<tm1Mtan>
Former Common nameOncostatin M receptor knockout mouse, OSMR-KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6NCrSlc
Appearanceblack [a/a B/B C/C]
Strain development1999年、田中稔先生、東京大学分子細胞生物学研究所C57BL/6　30 世代以上N8F20以上
Strain description軽度の貧血肝障害からの回復遅延
Colony maintenance繁殖効率 Bヘテロ型 x C57BL/6CrSlcホモ同士にて交配可能
References
Targeted disruption of oncostatin M receptor results in altered hematopoiesis.
Minoru Tanaka, Yoko Hirabayashi, Takashi Sekiguchi, Tohru Inoue, Motoya Katsuki, Atsushi Miyajima
Blood, 102, 3154-3162 (2003). 12855584

Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice.
Koji Nakamura, Hidenori Nonaka, Hiroki Saito, Minoru Tanaka, Atsushi Miyajima
Hepatology, 39, 635-644 (2004). 14999682

Health Report

Examination Date / Room / Rack2025/09/08Room:3-CRack:H囮検査
2025/06/30Room:3-CRack:H囮検査
2025/04/21Room:3-CRack:H囮検査
2025/01/20Room:3-CRack:H囮検査
2024/10/21Room:3-CRack:H囮検査
2024/07/22Room:3-CRack:H囮検査

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Osmr
MGI:1330819		oncostatin M receptor15Osmr<tm1Mtan>
MGI:2680723		targeted mutation 1, Minoru Tanaka
  • amyloidosis, primary localized cutaneous, 1(MedGEN)
    • lacZ beta-galactosidase (E. coli)15
    neo neomycin resistance gene (E. coli)15 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal adipose tissue morphology (MP:0000003)

  • abnormal adipose tissue physiology (MP:0005666)

  • abnormal circulating chemokine level (MP:0010209)

  • abnormal circulating serum amyloid protein level (MP:0010214)

  • abnormal common myeloid progenitor cell morphology (MP:0006410)
    • more 39 phenotypes
  • abnormal definitive hematopoiesis (MP:0002123)

  • abnormal erythroid progenitor cell morphology (MP:0008801)

  • abnormal liver physiology (MP:0000609)

  • abnormal megakaryocyte progenitor cell morphology (MP:0002413)

  • abnormal muscle physiology (MP:0002106)

  • anemia (MP:0001577)

  • decreased circulating adiponectin level (MP:0030968)

  • decreased circulating interleukin-10 level (MP:0008594)

  • decreased erythrocyte cell number (MP:0002875)

  • decreased hematocrit (MP:0000208)

  • decreased liver glycogen level (MP:0010398)

  • decreased megakaryocyte cell number (MP:0008255)

  • hepatic steatosis (MP:0002628)

  • impaired glucose tolerance (MP:0005293)

  • impaired liver regeneration (MP:0005517)

  • increased body weight (MP:0001260)

  • increased circulating cholesterol level (MP:0005178)

  • increased circulating free fatty acids level (MP:0001554)

  • increased circulating glucose level (MP:0005559)

  • increased circulating insulin level (MP:0002079)

  • increased circulating interleukin-10 level (MP:0008593)

  • increased circulating interleukin-6 level (MP:0008596)

  • increased circulating leptin level (MP:0005669)

  • increased circulating triglyceride level (MP:0001552)

  • increased circulating tumor necrosis factor level (MP:0008553)

  • increased epididymal fat pad weight (MP:0009288)

  • increased food intake (MP:0011939)

  • increased inflammatory response (MP:0001846)

  • increased liver cholesterol level (MP:0010027)

  • increased liver triglyceride level (MP:0009355)

  • increased liver weight (MP:0002981)

  • increased pancreatic beta cell number (MP:0003645)

  • increased subcutaneous adipose tissue amount (MP:0010934)

  • increased susceptibility to diet-induced obesity (MP:0005658)

  • increased white fat cell size (MP:0009118)

  • insulin resistance (MP:0005331)

  • polyphagia (MP:0001433)

  • thrombocytopenia (MP:0003179)

  • white adipose tissue inflammation (MP:0031602)
    • Detailed phenotype data

    Ordering Information

    供与核酸herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, E. coli lacZ, mouse Osmrg genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Hematological Research
    提供条件研究成果の公表にあたって寄託者の指定する文献を引用する。Blood, 102, 3154-3162 (2003). Hepatology, 39, 635-644 (2004). (株)カイオム・バイオサイエンス. Email:knakamura@chiome.co.jp の承諾を得る。
    Depositor宮島　篤（国立大学法人東京大学）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結精子より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    Feng Y, Yuan Y, Xia H, Wang Z, Che Y, Hu Z, Deng J, Li F, Wu Q, Bian Z, Zhou H, Shen D, Tang Q.
    OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling.
    J Transl Med 21(1) 290(2023) 37120549
    Hermans D, Houben E, Baeten P, Slaets H, Janssens K, Hoeks C, Hosseinkhani B, Duran G, Bormans S, Gowing E, Hoornaert C, Beckers L, Fung WK, Schroten H, Ishikawa H, Fraussen J, Thoelen R, de Vries HE, Kooij G, Zandee S, Prat A, Hellings N, Broux B.
    Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity.
    Acta Neuropathol 144(2) 259-281(2022) 35666306
    Zhang X, Li J, Qin JJ, Cheng WL, Zhu X, Gong FH, She Z, Huang Z, Xia H, Li H.
    Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages.
    J Lipid Res 58(5) 895-906(2017) 28258089
    Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y.
    The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
    Nat Commun 8 13946(2017) 28067314
    Janssens K, Maheshwari A, Van den Haute C, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N.
    Oncostatin M protects against demyelination by inducing a protective microglial phenotype.
    Glia 63(10) 1729-37(2015) 25921393
    Guo S, Li ZZ, Gong J, Xiang M, Zhang P, Zhao GN, Li M, Zheng A, Zhu X, Lei H, Minoru T, Li H.
    Oncostatin M Confers Neuroprotection against Ischemic Stroke.
    J Neurosci 35(34) 12047-62(2015) 26311783