Strain Data Sheet

RBRC02711

Strain Information

Image
BRC No.RBRC02711
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Osmr<tm1Mtan>
Former Common nameOncostatin M receptor knockout mouse, OSMR-KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6NCrSlc
Appearanceblack [a/a B/B C/C]
Strain development1999年、田中稔先生、東京大学分子細胞生物学研究所C57BL/6　30 世代以上N8F20以上
Strain description軽度の貧血肝障害からの回復遅延
Colony maintenance繁殖効率 Bヘテロ型 x C57BL/6CrSlcホモ同士にて交配可能
ReferencesHepatology, 39, 635-644 (2004). 14999682
Blood, 102, 3154-3162 (2003). 12855584

Health Report

Examination Date / Room / Rack2024/01/22Room:3-CRack:H
2023/10/23Room:3-CRack:H
2023/07/24Room:3-CRack:H
2023/04/24Room:3-CRack:H
2023/01/23Room:3-CRack:H
2022/10/25Room:3-CRack:H
2022/07/25Room:3-CRack:H

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Osmroncostatin M receptor15Osmr<tm1Mtan>targeted mutation 1, Minoru TanakaOSMRB

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
lacZbeta-galactosidase (E. coli)15

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)15neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Ordering Information

供与核酸herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, E. coli lacZ, mouse Osmrg genomic DNA
Research applicationFluorescent Proteins/lacZ System
Hematological Research
提供条件条件を付加する。
研究成果の公表にあたって寄託者の指定する文献を引用する。Blood, 102, 3154-3162 (2003). Hepatology, 39, 635-644 (2004).
(株)カイオム・バイオサイエンス. Email:knakamura@chiome.co.jp の承諾を得る。
Depositor宮島　篤（国立大学法人東京大学）
Strain Status生体のアイコン生体
凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
生体マウスを1~3ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

Hermans D, Houben E, Baeten P, Slaets H, Janssens K, Hoeks C, Hosseinkhani B, Duran G, Bormans S, Gowing E, Hoornaert C, Beckers L, Fung WK, Schroten H, Ishikawa H, Fraussen J, Thoelen R, de Vries HE, Kooij G, Zandee S, Prat A, Hellings N, Broux B.
Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity.
Acta Neuropathol 144(2) 259-281(2022) 35666306

Janssens K, Maheshwari A, Van den Haute C, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N.
Oncostatin M protects against demyelination by inducing a protective microglial phenotype.
Glia 63(10) 1729-37(2015) 25921393

Guo S, Li ZZ, Gong J, Xiang M, Zhang P, Zhao GN, Li M, Zheng A, Zhu X, Lei H, Minoru T, Li H.
Oncostatin M Confers Neuroprotection against Ischemic Stroke.
J Neurosci 35(34) 12047-62(2015) 26311783

Feng Y, Yuan Y, Xia H, Wang Z, Che Y, Hu Z, Deng J, Li F, Wu Q, Bian Z, Zhou H, Shen D, Tang Q.
OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling.
J Transl Med 21(1) 290(2023) 37120549

Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y.
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
Nat Commun 8 13946(2017) 28067314