Strain Data Sheet

RBRC02684

Strain Information

Image
BRC No.RBRC02684
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6J.C-Atp2b2<wri>/Oda
Former Common name
H-2 Haplotype
ES Cell line
Background strainC57BL/6
Appearanceblack [a/a B/B C/C]
Strain developmentSpontaneous mutant arose in BALB/c inbred mice, found by Mr. Michio Ohmura, Ohmura Institute for Laboratory Animals in 1984. The Wriggle mice were maintained by Dr. Nobutaka Ohsawa, Kitasato University School of Medicine, and then backcrossed to C57BL/6J by Dr. Sen-ichi Oda, Nagoya University in 2005.
Strain descriptionWriggle Mouse Sagami (wri), a point mutation was occurred in a Atp2b2 gene that is an isoform of Calmodulin-dependent plasma membrane Ca<2+>-ATPase. Homozygous mutant mice show severe dystonic movements of the trunk and extremities.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJmsSlc]Homozygous mutant mice are viable, but infertile due to a failure of mating behavior.
References
A point mutation in a plasma membrane Ca(2+)-ATPase gene causes deafness in Wriggle Mouse Sagami.
Takahashi K, Kitamura K
Biochem. Biophys. Res. Commun., 261, 773-778 (1999). 10441500

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Atp2b2ATPase, Ca++ transporting, plasma membrane 26Atp2b2wriggle
  • autosomal recessive nonsyndromic hearing loss 12(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal Purkinje cell differentiation(MP:0008579)

  • abnormal Purkinje cell innervation(MP:0003894)

  • abnormal gait(MP:0001406)

  • abnormal motor coordination/balance(MP:0001516)

  • abnormal postural reflex(MP:0002980)
  • more 8 phenotypes
  • abnormal vestibular saccule morphology(MP:0006089)

  • cochlear degeneration(MP:0000032)

  • cochlear ganglion degeneration(MP:0002857)

  • cochlear outer hair cell degeneration(MP:0004404)

  • deafness(MP:0001967)

  • increased or absent threshold for auditory brainstem response(MP:0011967)

  • tremors(MP:0000745)

  • vestibular saccular degeneration(MP:0004329)
  • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationNeurobiology Research
    Sensorineural Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
    DepositorSenichi Oda (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data