Strain Data Sheet

RBRC02683

Strain Information

Image
BRC No.RBRC02683
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6J.Cg-Atp2b2<jog>/Oda
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
A novel mutant mouse, joggle, with inherited ataxia.
Ziyan Chen, Shizu Hayasaka, Yoshiko Takagishi, Yoshiharu Murata, Sen-ichi Oda
Exp. Anim., 55, 411-414 (2006). 16880690

Mapping of jog locus to the region between D6Mit104 and D6Mit336 on mouse chromosome 6.
Xiao-yang Sun, Zi-yan Chen, Yasuhiko Kanou, Yoshiko Takagishi, Yoshitaka Hayashi, Tamio Ohno, Yoshiharu Murata, Sen-ichi Oda
Exp. Anim., 56, 389-392 (2007). 18075201

Insertion of an intracisternal A particle retrotransposon element in plasma membrane calcium ATPase 2 gene attenuates its expression and produces an ataxic phenotype in joggle mutant mice.
Xiao-yang Sun, Zi-yan Chen, Yoshitaka Hayashi, Yasuhiko Kanou, Yoshiko Takagishi, Sen-ichi Oda, Yoshiharu Murata
Gene, 411, 94-102 (2008) 18280673

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Atp2b2
MGI:105368		ATPase, Ca++ transporting, plasma membrane 26Atp2b2<jog>
MGI:3664103		joggle
  • autosomal recessive nonsyndromic hearing loss 12(MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal cell death (MP:0000313)

  • abnormal posture (MP:0001504)

  • ataxia (MP:0001393)

  • decreased body weight (MP:0001262)

  • impaired limb coordination (MP:0001524)
    • more 3 phenotypes
  • limb grasping (MP:0001513)

  • small cerebellum (MP:0000852)

  • tremors (MP:0000745)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationSensorineural Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
    DepositorSenichi Oda (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data