Strain Data Sheet

RBRC02524

Strain Information

Image
BRC No.RBRC02524
TypeTransgene Congenic and Spontaneous MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(HRAS)2Mok Kit<W>
Former Common nameHRAS Tg W mutant, B6-HRAS Tg#2/W
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptionhuman HRAS transgene and Kit<W> double mutant mice.
Colony maintenance
References
Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes.
Saitoh A, Kimura M, Takahashi R, Yokoyama M, Nomura T, Izawa M, Sekiya T, Nishimura S, Katsuki M
Oncogene. 1990 5(8):1195-200. 2202951

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Kit
MGI:96677		KIT proto-oncogene receptor tyrosine kinase5Kit<W>
MGI:1856232		dominant spotting
  • acute myeloid leukemia(DisGeNET, MedGEN)

  • cutaneous mastocytosis(MedGEN)

  • gastrointestinal stromal tumor(DisGeNET, MedGEN)
    • more 3 Diseases
  • mastocytosis(DisGeNET)

  • piebaldism(DisGeNET, MedGEN)

  • testicular germ cell tumor(MedGEN)
    • HRAS Harvey rat sarcoma virus oncogene (human)UNHRAS
    neo neomycin resistance gene (E. coli)UN

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal B cell differentiation(MP:0002144)

  • abnormal Sertoli cell morphology(MP:0002784)

  • abnormal T cell differentiation(MP:0002145)

  • abnormal body temperature(MP:0005535)

  • abnormal coat/hair pigmentation(MP:0002075)
    • more 53 phenotypes
  • abnormal digestive system physiology(MP:0001663)

  • abnormal eye pigmentation(MP:0001324)

  • abnormal histamine physiology(MP:0002503)

  • abnormal interferon level(MP:0008750)

  • abnormal interleukin level(MP:0008751)

  • abnormal interstitial cell of Cajal morphology(MP:0009536)

  • abnormal muscle physiology(MP:0002106)

  • abnormal ovarian follicle number(MP:0008871)

  • abnormal renal glomerulus morphology(MP:0005325)

  • abnormal response to cardiac infarction(MP:0000343)

  • abnormal response to transplant(MP:0005671)

  • abnormal response/metabolism to endogenous compounds(MP:0003638)

  • abnormal spermatogenesis(MP:0001156)

  • abnormal survival(MP:0010769)

  • abnormal ventral coat pigmentation(MP:0008237)

  • absent coat pigmentation(MP:0005171)

  • decreased B cell number(MP:0005017)

  • decreased airway responsiveness(MP:0002335)

  • decreased basophil cell number(MP:0002607)

  • decreased body weight(MP:0001262)

  • decreased inflammatory response(MP:0001876)

  • decreased mast cell number(MP:0000336)

  • decreased susceptibility to induced arthritis(MP:0003436)

  • decreased susceptibility to type I hypersensitivity reaction(MP:0005597)

  • decreased thymocyte number(MP:0000715)

  • decreased vascular permeability(MP:0003071)

  • glomerular crescent(MP:0011506)

  • hematopoietic system phenotype(MP:0005397)

  • hepatic steatosis(MP:0002628)

  • high mean erythrocyte cell number(MP:0002593)

  • immune system phenotype(MP:0005387)

  • impaired neutrophil recruitment(MP:0008719)

  • increased erythrocyte protoporphyrin level(MP:0011188)

  • increased esophageal papilloma incidence(MP:0003277)

  • increased hematocrit(MP:0002608)

  • increased myocardial infarct size(MP:0003037)

  • increased papilloma incidence(MP:0002014)

  • increased susceptibility to induced morbidity/mortality(MP:0009763)

  • increased susceptibility to xenobiotic induced morbidity/mortality(MP:0009766)

  • increased urine protein level(MP:0002962)

  • infertility(MP:0001924)

  • irregular coat pigmentation(MP:0000372)

  • kidney inflammation(MP:0001859)

  • macrocytic anemia(MP:0002811)

  • peptic ulcer(MP:0003301)

  • perinatal lethality, incomplete penetrance(MP:0011090)

  • postnatal lethality, complete penetrance(MP:0011085)

  • prenatal lethality(MP:0002080)

  • prenatal lethality, complete penetrance(MP:0011091)

  • reproductive system phenotype(MP:0005389)

  • small ovary(MP:0001127)

  • small testis(MP:0001147)

  • variable body spotting(MP:0002940)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli neo, human rasH2 genimic DNA, mouse kit oncogene
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Oncogene, 5, 1195-1200 (1990).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data