Strain Data Sheet

RBRC02522

Strain Information

Image
BRC No.RBRC02522
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Drd1a<tm1Mok> Drd1a<tm1(tTA)Mok> Tg(TRE-Drd1a/lacZ)1Mok
Former Common nameD1TET, LacZD1R KO, B6-D1R KO D1R/tTA TRE-D1R/lacZ
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptionD1R (Drd1a) knockout, D1R-tTA knock-in and TRE-D1R/lacZ transgene triple mutant mice.
Colony maintenance
References
Dopamine D1 receptor modulates hippocampal representation plasticity to spatial novelty.
Tran A H, Uwano T, Kimura T, Hori E, Katsuki M, Nishijo H, Ono T
J. Neurosci., 28(50):13390-13400 (2008). 19074012

Distinct motor impairments of dopamine D1 and D2 receptor knockout mice revealed by three types of motor behavior.
Nakamura T, Sato A, Kitsukawa T, Momiyama T, Yamamori T, Sasaoka T
Front Integr Neurosci., 8:56 (2014). 25076876

Dopamine D1 Receptor-Mediated Transmission Maintains Information Flow Through the Cortico-Striato-Entopeduncular Direct Pathway to Release Movements.
Chiken S, Sato A, Ohta C, Kurokawa M, Arai S, Maeshima J, Sunayama-Morita T, Sasaoka T, Nambu A
Cerebral Cortex., 25(12):4885-4897 (2015). 26443442

Expression pattern of immediate early genes in the cerebellum of D1R KO, D2R KO, and wild type mice under vestibular-controlled activity.
Nakamura T, Sato A, Kitsukawa T, Sasaoka T, Yamamori T
Front Cell Dev Biol., 3:38 (2015). 26137459

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Drd1
MGI:99578		dopamine receptor D113Drd1<tm1Mok>
MGI:3829942		targeted mutation 1, Motoya Katsuki
Drd1
MGI:99578		dopamine receptor D113Drd1<tm1Mok>
MGI:3829942		targeted mutation 1, Motoya Katsuki
neo neomycin resistance gene (E. coli)13 mouse phosphoglycerate kinase promoter (PGK promoter)
tTA tTA (E. coli tet repressor (TetR), herpes simplex virus (HSV) VP16 activation domain)13tTA
Drd1
MGI:99578		dopamine receptor D1AUNDrd1 E. coli TRE promoter (tetracycline responsive promoter)
lacZ beta-galactosidase (E. coli)UN

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal synaptic plasticity(MP:0004859)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Dopamine receptor 1 genomic DNA, E. coli neo, E. coli xanthine phosphoribosyltransferase (Ecogpt)tTA (E. coli tet repressor (TetR), herpes simplex virus (HSV) VP16 activation domain), E. coli tetracycline operator, E. coli lacZ
    Research applicationFluorescent Proteins/lacZ System
    Tet system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cerebral Cortex., 25, 4885-4897 (2015).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki and Dr. Toshikuni Sasaoka is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data