Strain Data Sheet

RBRC02488

Strain Information

Image
BRC No.RBRC02488
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Il6st<tm1> Hras1<tm1Mok> Nras<tm1Mok>
Former Common namegp130, H-ras, N-ras triple KO, B6-gp130/Hras/Nras KO, B6.129-Il6st<tm1> Hras1<tm1Mok> Nras<tm1Mok>
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptiongp130 (Il6st), Hras and Nras genes triple knockout mice.
Colony maintenance
References
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Ise K, Nakamura K, Nakao K, Shimizu S, Harada H, Ichise T, Miyoshi J, Gondo Y, Ishikawa T, Aiba A, Katsuki M
Oncogene, 19(26):2951-2956 (2000). 10871846

K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development.
Matsui T, Kinoshita T, Morikawa Y, Tohya K, Katsuki M, Ito Y, Kamiya A, Miyajima A
EMBO J. 21(5):1021-30 (2002). 11867530

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Il6st
MGI:96560		interleukin 6 signal transducer13Il6st<tm1> targeted mutation 1
  • hyper-IgE recurrent infection syndrome 4, autosomal recessive(MedGEN)
    • Csde1
    MGI:92356    		cold shock domain containing E1, RNA binding3Csde1
    Nras
    MGI:97376    		neuroblastoma ras oncogene3Nras<tm1Mok>
    MGI:3794957    		targeted mutation 1, Motoya Katsuki
  • autoimmune lymphoproliferative syndrome type 4(MedGEN)

  • colorectal cancer(MedGEN)

  • colorectal carcinoma(DisGeNET)
    • more 7 Diseases
  • juvenile myelomonocytic leukemia(DisGeNET)

  • large congenital melanocytic nevus(MedGEN)

  • linear nevus sebaceous syndrome(MedGEN)

  • neurocutaneous melanocytosis(MedGEN)

  • nevus, epidermal(MedGEN)

  • Noonan syndrome 6(MedGEN)

  • thyroid cancer, nonmedullary, 2(MedGEN)
    • neo neomycin resistance gene (E. coli)3 herpes simplex virus thymidine kinase promoter (HSV tk promoter)
    Hras
    MGI:96224    		Harvey rat sarcoma virus oncogene7Hras<tm1Mok>
    MGI:2386128    		targeted mutation 1, Motoya Katsuki
  • Costello syndrome(DisGeNET, MedGEN)

  • large congenital melanocytic nevus(MedGEN)

  • linear nevus sebaceous syndrome(MedGEN)
    • more 4 Diseases
  • melanoma(DisGeNET)

  • nevus, epidermal(MedGEN)

  • thyroid cancer, nonmedullary, 2(MedGEN)

  • urinary bladder cancer(MedGEN)
    • neo neomycin resistance gene7

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • chylous ascites(MP:0012080)

  • decreased incidence of tumors by chemical induction(MP:0004502)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli neo, mouse gp130 genomic DNA, mouse H-ras genomic DNA, mouse N-ras genomic DNA
    Research applicationImmunology and Inflammation Research
    covid19_onset
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Oncogene, 19, 2951-2956 (2000). EMBO J., 21, 1021-1030 (2000).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data