Strain Information | |
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Image | |
BRC No. | RBRC02487 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Il6st<tm1> Hras1<tm1Mok> |
Former Common name | gp130, H-ras double KO, B6-gp130/Hras KO |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Motoya Katsuki, National Institutes of Natural Sciences. |
Strain description | gp130 (Il6st) and Hras genes double knockout mice. |
Colony maintenance | |
References | Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Ise K, Nakamura K, Nakao K, Shimizu S, Harada H, Ichise T, Miyoshi J, Gondo Y, Ishikawa T, Aiba A, Katsuki M Oncogene, 19(26):2951-2956 (2000). 10871846 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Il6st | interleukin 6 signal transducer | 13 | Il6st | targeted mutation 1 | |||
Hras | Harvey rat sarcoma virus oncogene | 7 | Hras | targeted mutation 1, Motoya Katsuki | |||
neo | neomycin resistance gene (E. coli) | 7 |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | E. coli neo, mouse gp130 genomic DNA, mouse H-ras genomic DNA |
Research application | Immunology and Inflammation Research covid19_onset |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Oncogene, 19, 2951-2956 (2000).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Toshikuni Sasaoka (Niigata University) |
Strain Status | Frozen embryos |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |