Strain Data Sheet

RBRC02481

Strain Information

Image
BRC No.RBRC02481
TypeTargeted Mutation and TransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Hras1<tm1Mok> Tg(HRAS)2Mok Tg(Hras)1Mok
Former Common nameH-ras-KO, rasH2 Tg, mouse H-ras Tg, B6-Hras KO/HRAS Tg#2/Hras Tg
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain development基礎生物学研究所・勝木元也。
Strain descriptionHras遺伝子、ヒトHRASトランスジーンならびにマウスHrasトランスジーンのトリプルミュータントマウス。
Colony maintenance
References
Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes.
Saitoh A, Kimura M, Takahashi R, Yokoyama M, Nomura T, Izawa M, Sekiya T, Nishimura S, Katsuki M
Oncogene, 5, 1195-1200 (1990). 2202951

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Ise K, Nakamura K, Nakao K, Shimizu S, Harada H, Ichise T, Miyoshi J, Gondo Y, Ishikawa T, Aiba A, Katsuki M
Oncogene, 19, 2951-2956 (2000). 10871846

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Hras
MGI:96224		Harvey rat sarcoma virus oncogene7Hras<tm1Mok>
MGI:2386128		targeted mutation 1, Motoya Katsuki
  • Costello syndrome(DisGeNET, MedGEN)

  • large congenital melanocytic nevus(MedGEN)

  • linear nevus sebaceous syndrome(MedGEN)
    • more 4 Diseases
  • melanoma(DisGeNET)

  • nevus, epidermal(MedGEN)

  • thyroid cancer, nonmedullary, 2(MedGEN)

  • urinary bladder cancer(MedGEN)
    • neo neomycin resistance gene (E. coli)7

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • chylous ascites (MP:0012080)

  • decreased incidence of tumors by chemical induction (MP:0004502)

  • homeostasis/metabolism phenotype (MP:0005376)
    • Detailed phenotype data

    Ordering Information

    供与核酸E. coli neo, mouse H-ras, human H-ras
    Research application
    提供条件研究成果の公表にあたって寄託者の指定する文献を引用する。Oncogene, 19, 2951-2956 (2000). Oncogene, 5, 1195-1200 (1990).利用者は、研究成果の公表にあたって、勝木元也博士へ謝辞の表明を必要とする。利用者が本件リソースを使用して得られた研究成果に基づき特許等の申請、及び事業活動を行う場合は、寄託者と別途協議を行う。
    Depositor笹岡　俊邦（国立大学法人新潟大学）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability受注後、検査を施して提供
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data