Strain Data Sheet

RBRC02455

Strain Information

Image
BRC No.RBRC02455
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameCBy.Cg-Drd2<tm1Mok>/Q
Former Common nameD2R/Q-KO BALB/cByJ, BALB-D2R KO/Q
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences (Medical Institute of Bioregulation, Kyushu University).
Strain descriptionD2R (Drd2) gene knockout mice (Line Q). BALB/c background.
Colony maintenanceHeterozygote x Wild-type [or Crossing to BALB/cByJJcl]
References
Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Yamaguchi H, Aiba A, Nakamura K, Nakao K, Sakagami H, Goto K, Kondo H, Katsuki M
Genes Cells. 1(2):253-68 (1996). 9140068

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Drd2
MGI:94924		dopamine receptor D29Drd2<tm1Mok>
MGI:3576789		targeted mutation 1, Motoya Katsuki
neo neomycin resistance gene (E. coli)9 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal circulating hormone level(MP:0005418)

  • abnormal single cell response(MP:0003463)

  • darkened coat color(MP:0005409)

  • enlarged pituitary intermediate lobe(MP:0008370)

  • increased pituitary hormone level(MP:0003973)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli neo, mouse Dopamine receptor2 genomic DNA
    Research applicationNeurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Cells, 1, 253-268 (1996).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data