Strain Data Sheet

RBRC02448

Strain Information

Image
BRC No.RBRC02448
TypeTransgene and Spontaneous MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(HRAS)2Mok Kit<W> Kit<W-v>
Former Common namerasH2Tg, W,W<v> mutant, B6-W/Wv HRAS Tg#2
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptionKit<W>, Kit<Wv> and human HRAS transnene triple mutant mice.
Colony maintenance
References
Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes.
Saitoh A, Kimura M, Takahashi R, Yokoyama M, Nomura T, Izawa M, Sekiya T, Nishimura S, Katsuki M
Oncogene. 1990 5(8):1195-200. 2202951

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Kit
MGI:96677		KIT proto-oncogene receptor tyrosine kinase5Kit<W>
MGI:1856232		dominant spotting
  • acute myeloid leukemia(DisGeNET, MedGEN)

  • cutaneous mastocytosis(MedGEN)

  • gastrointestinal stromal tumor(DisGeNET, MedGEN)
    • more 3 Diseases
  • mastocytosis(DisGeNET)

  • piebaldism(DisGeNET, MedGEN)

  • testicular germ cell tumor(MedGEN)
    • Kit
    MGI:96677    		KIT proto-oncogene receptor tyrosine kinase5Kit<W-v>
    MGI:1856266    		viable dominant spotting
  • acute myeloid leukemia(DisGeNET, MedGEN)

  • cutaneous mastocytosis(MedGEN)

  • gastrointestinal stromal tumor(DisGeNET, MedGEN)
    • more 3 Diseases
  • mastocytosis(DisGeNET)

  • piebaldism(DisGeNET, MedGEN)

  • testicular germ cell tumor(MedGEN)
    • HRAS Harvey rat sarcoma virus oncogene (human)UNHRAS
    neo neomycin resistance gene (E. coli)UN

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal B cell differentiation(MP:0002144)

  • abnormal Sertoli cell morphology(MP:0002784)

  • abnormal body temperature(MP:0005535)

  • abnormal coat/hair pigmentation(MP:0002075)

  • abnormal cochlea morphology(MP:0000031)
    • more 79 phenotypes
  • abnormal cochlear ganglion morphology(MP:0002855)

  • abnormal cochlear outer hair cell morphology(MP:0004399)

  • abnormal definitive hematopoiesis(MP:0002123)

  • abnormal ear pigmentation(MP:0000015)

  • abnormal erythrocyte cell number(MP:0001586)

  • abnormal eye pigmentation(MP:0001324)

  • abnormal histamine physiology(MP:0002503)

  • abnormal interferon level(MP:0008750)

  • abnormal interleukin level(MP:0008751)

  • abnormal interstitial cell of Cajal morphology(MP:0009536)

  • abnormal melanocyte morphology(MP:0002877)

  • abnormal melanogenesis(MP:0005077)

  • abnormal melanosome morphology(MP:0005075)

  • abnormal muscle physiology(MP:0002106)

  • abnormal organ of Corti morphology(MP:0000042)

  • abnormal otolith morphology(MP:0002894)

  • abnormal ovarian follicle number(MP:0008871)

  • abnormal renal glomerulus morphology(MP:0005325)

  • abnormal response to cardiac infarction(MP:0000343)

  • abnormal response/metabolism to endogenous compounds(MP:0003638)

  • abnormal spermatogenesis(MP:0001156)

  • abnormal stria vascularis morphology(MP:0000048)

  • abnormal stria vascularis vasculature morphology(MP:0004368)

  • abnormal strial basal cell morphology(MP:0004365)

  • abnormal strial marginal cell morphology(MP:0004366)

  • abnormal survival(MP:0010769)

  • abnormal tectorial membrane morphology(MP:0003149)

  • abnormal ventral coat pigmentation(MP:0008237)

  • abnormal vestibular saccule morphology(MP:0006089)

  • absent coat pigmentation(MP:0005171)

  • absent endocochlear potential(MP:0004410)

  • absent strial intermediate cells(MP:0006010)

  • belly spot(MP:0000373)

  • cochlear ganglion degeneration(MP:0002857)

  • decreased B cell number(MP:0005017)

  • decreased airway responsiveness(MP:0002335)

  • decreased basophil cell number(MP:0002607)

  • decreased body weight(MP:0001262)

  • decreased inflammatory response(MP:0001876)

  • decreased mast cell number(MP:0000336)

  • decreased susceptibility to induced arthritis(MP:0003436)

  • decreased tumor incidence(MP:0002052)

  • decreased vascular permeability(MP:0003071)

  • delayed female fertility(MP:0008976)

  • diluted coat color(MP:0000371)

  • enlarged otoliths(MP:0003143)

  • glomerular crescent(MP:0011506)

  • head spot(MP:0002939)

  • hematopoietic system phenotype(MP:0005397)

  • high mean erythrocyte cell number(MP:0002593)

  • hypopigmentation(MP:0005408)

  • immune system phenotype(MP:0005387)

  • impaired neutrophil recruitment(MP:0008719)

  • increased bleeding time(MP:0005606)

  • increased erythrocyte protoporphyrin level(MP:0011188)

  • increased esophageal papilloma incidence(MP:0003277)

  • increased hematocrit(MP:0002608)

  • increased melanoma incidence(MP:0010275)

  • increased myocardial infarct size(MP:0003037)

  • increased papilloma incidence(MP:0002014)

  • increased susceptibility to induced morbidity/mortality(MP:0009763)

  • increased susceptibility to xenobiotic induced morbidity/mortality(MP:0009766)

  • increased urine protein level(MP:0002962)

  • irregular coat pigmentation(MP:0000372)

  • kidney inflammation(MP:0001859)

  • macrocytic anemia(MP:0002811)

  • mosaic coat color(MP:0010389)

  • peptic ulcer(MP:0003301)

  • postnatal lethality, complete penetrance(MP:0011085)

  • premature death(MP:0002083)

  • prenatal lethality(MP:0002080)

  • reduced fertility(MP:0001921)

  • reproductive system phenotype(MP:0005389)

  • small ovary(MP:0001127)

  • small testis(MP:0001147)

  • thin stria vascularis(MP:0004364)

  • variable body spotting(MP:0002940)

  • vestibular hair cell degeneration(MP:0004324)

  • white spotting(MP:0002938)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli neo, human rasH2 genomic DNA, mouse kit oncogene
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Oncogene, 5, 1195-1200 (1990).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data