Strain Data Sheet

RBRC02442

Strain Information

Image
BRC No.RBRC02442
TypeTransgene and Spontaneous MutationCartagena
SpeciesMus musculus
Strain nameMRL/MpJ-lpr-Tg(dLck-Fas)
Former Common nameT&B Tg lpr, Mm-MRL/MpJ-lpr/lpr-TgN(dLck-Fas)
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Requirement of Fas expression in B cells for tolerance induction.
Fukuyama H, Adachi M, Suematsu S, Miwa K, Suda T, Yoshida N, Nagata S
Eur. J. Immunol., 32, 223-230 (2002). 11782013

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Fas
MGI:95484		Fas cell surface death receptor19Fas<lpr>
MGI:1856334		lymphoproliferation
  • autoimmune lymphoproliferative syndrome type 1(DisGeNET, MedGEN)
    • Fas Fas (TNF receptor superfamily member)UNFas mouse lck distal promoter

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • phenotypic reversion by gene product interaction(MP:0011955)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Lck distal promoter, mouse Fas cDNA
    Research applicationApoptosis Research
    Immunology and Inflammation Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Eur. J. Immunol., 32, 223-230 (2002).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. The RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.
    DepositorShigekazu Nagata (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data