Strain Data Sheet

RBRC02441

Strain Information

Image
BRC No.RBRC02441
TypeTargeted Mutation and TransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Kras<tm1Mok> Tg(HRAS/floxed)1Mok
Former Common nameK-rasKO, L-rasTg, B6-Kras KO/Lras Tg
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain development基礎生物学研究所・勝木元也。
Strain descriptionKras遺伝子のノックアウトとLras Tgのダブルミュータントマウス。
Colony maintenance
References
K-ras is essential for the development of the mouse embryo.
Koera K, Nakamura K, Nakao K, Miyoshi J, Toyoshima K, Hatta T, Otani H, Aiba A, Katsuki M
Oncogene, 15, 1151-1159 (1997). 9294608

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Kras
MGI:96680		Kirsten rat sarcoma viral oncogene homolog6Kras<tm1Mok>
MGI:1857551		targeted mutation 1, Motoya Katsuki
  • acute myeloid leukemia(MedGEN)

  • arteriovenous malformations of the brain(MedGEN)

  • autoimmune lymphoproliferative syndrome type 4(MedGEN)
    • more 12 Diseases
  • cardiofaciocutaneous syndrome 2(MedGEN)

  • cardiofaciocutaneous syndrome(DisGeNET)

  • exocrine pancreatic carcinoma(MedGEN)

  • gastric cancer(MedGEN)

  • hereditary breast carcinoma(MedGEN)

  • juvenile myelomonocytic leukemia(DisGeNET)

  • linear nevus sebaceous syndrome(MedGEN)

  • lung cancer(MedGEN)

  • Noonan syndrome 3(DisGeNET, MedGEN)

  • Noonan syndrome(DisGeNET)

  • Toriello-Lacassie-Droste syndrome(MedGEN)

  • urinary bladder cancer(MedGEN)
    • HRAS Harvey rat sarcoma virus oncogene (human)UNHRAS
    loxP phage P1 loxPUNloxP
    loxP phage P1 loxPUNloxP

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal fetal cardiomyocyte proliferation (MP:0003567)

  • abnormal heart morphology (MP:0000266)

  • decreased embryo size (MP:0001698)

  • embryonic growth retardation (MP:0003984)

  • hematopoietic system phenotype (MP:0005397)
    • more 5 phenotypes
  • increased neuron apoptosis (MP:0003203)

  • prenatal lethality, complete penetrance (MP:0011091)

  • small heart (MP:0002188)

  • thin myocardium (MP:0002652)

  • thin ventricular wall (MP:0000280)
    • Detailed phenotype data

    Ordering Information

    供与核酸E. coli neo, mouse K-ras, human H-ras genomic DNA
    Research application
    提供条件研究成果の公表にあたって寄託者の指定する文献を引用する。Oncogene, 15, 1151-1159 (1997).利用者は、研究成果の公表にあたって、勝木元也博士へ謝辞の表明を必要とする。利用者が本件リソースを使用して得られた研究成果に基づき特許等の申請、及び事業活動を行う場合は、寄託者と別途協議を行う。
    Depositor笹岡　俊邦（国立大学法人新潟大学）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability受注後、検査を施して提供
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data