Strain Data Sheet

RBRC02441

update : 2025-03-19

Strain Information
Image
BRC No.	RBRC02441
Type	Targeted Mutation and Transgene
Species	Mus musculus
Strain name	B6.Cg-Kras<tm1Mok> Tg(HRAS/floxed)1Mok
Former Common name	K-rasKO, L-rasTg, B6-Kras KO/Lras Tg
H-2 Haplotype
ES Cell line	CCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain development	Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description	Double mutant mice having a Kras gene knockout and Lras transgene.
Colony maintenance
References	K-ras is essential for the development of the mouse embryo. Koera K, Nakamura K, Nakao K, Miyoshi J, Toyoshima K, Hatta T, Otani H, Aiba A, Katsuki M Oncogene, 15, 1151-1159 (1997). 9294608

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
Kras MGI:96680	Kirsten rat sarcoma viral oncogene homolog	6	Kras<tm1Mok> MGI:1857551	targeted mutation 1, Motoya Katsuki			acute myeloid leukemia(MedGEN) arteriovenous malformations of the brain(MedGEN) autoimmune lymphoproliferative syndrome type 4(MedGEN) more 12 Diseases cardiofaciocutaneous syndrome 2(MedGEN) cardiofaciocutaneous syndrome(DisGeNET) exocrine pancreatic carcinoma(MedGEN) gastric cancer(MedGEN) hereditary breast carcinoma(MedGEN) juvenile myelomonocytic leukemia(DisGeNET) linear nevus sebaceous syndrome(MedGEN) lung cancer(MedGEN) Noonan syndrome 3(DisGeNET, MedGEN) Noonan syndrome(DisGeNET) Toriello-Lacassie-Droste syndrome(MedGEN) urinary bladder cancer(MedGEN)
HRAS	Harvey rat sarcoma virus oncogene (human)	UN	HRAS
loxP	phage P1 loxP	UN	loxP
loxP	phage P1 loxP	UN	loxP

Phenotype
Annotation by Mammalian phenotyhpe ontology	abnormal fetal cardiomyocyte proliferation(MP:0003567) abnormal heart morphology(MP:0000266) decreased embryo size(MP:0001698) embryonic growth retardation(MP:0003984) hematopoietic system phenotype(MP:0005397) more 5 phenotypes increased neuron apoptosis(MP:0003203) prenatal lethality, complete penetrance(MP:0011091) small heart(MP:0002188) thin myocardium(MP:0002652) thin ventricular wall(MP:0000280)
Detailed phenotype data

Annotation by Mammalian phenotyhpe ontology

abnormal fetal cardiomyocyte proliferation(MP:0003567)

abnormal heart morphology(MP:0000266)

decreased embryo size(MP:0001698)

embryonic growth retardation(MP:0003984)

hematopoietic system phenotype(MP:0005397)

more 5 phenotypes

increased neuron apoptosis(MP:0003203)

prenatal lethality, complete penetrance(MP:0011091)

small heart(MP:0002188)

thin myocardium(MP:0002652)

thin ventricular wall(MP:0000280)

Detailed phenotype data

Ordering Information
Donor DNA	E. coli neo, mouse K-ras, human H-ras genomic DNA
Research application
Specific Term and Conditions	In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Oncogene, 15, 1151-1159 (1997).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Depositor	Toshikuni Sasaoka (Niigata University)
Strain Status	Frozen embryos
Strain Availability	Recovery and QC required prior to distribution
Additional Info.	Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data