Strain Data Sheet

RBRC02428

Information1

Image
BRC No.RBRC02428
TypeTargeted Mutation and TransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Kras<tm1Mok> Trp53<tm2Mok> Tg(hKrasPAC)1Mok
Former Common namemouse K-ras, p53 KO, K-ras(PAC)Tg, B6-Kras KO/p53 KO/KrasPAC Tg
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptionTriple mutant mice having a Kras gene knockout, p53 (Trp53) knockout (lacZ reporter) and human KRAS transgenene.
Colony maintenance
ReferencesOncogene, 15, 1151-1159 (1997). 9294608
Biochem. Biophys. Res. Commun., 1994 202(2):830-7. 8048955

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Trp53transformation related protein 5311Trp53<tm2Mok>targeted mutation 2, Motoya Katsukip53

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
lacZbeta-galactosidase (E. coli)11

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)11neo; neomycin;

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Krasv-Ki-ras2 Kirsten rat sacroma viral oncogene homolog6KrasK-ras, Ki-ras, Kras-2, Kras2

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
KRASv-Ki-ras2 Kirsten rat sacroma viral oncogene homolog (human)UNKRASK-ras, Ki-ras, Kras-2, Kras2

Information2

Donor DNAE.coli neo, mouse K-ras, mouse p53, human K-ras oncogene genomic DNA
Research applicationCancer Research
Cell Biology Research
Immunology and Inflammation Research
Mouse Models for Human Disease
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Oncogene, 15, 1151-1159 (1997). Biochem. Biophys. Res. Commun., 202, 830-837 (1994). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorToshikuni Sasaoka (Niigata University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data