Strain Data Sheet

RBRC02427

Strain Information

Image
BRC No.RBRC02427
TypeTargeted Mutation and TransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Kras<tm1Mok> Tg(hKrasPAC)1Mok
Former Common nameK-ras KO, K-ras(PAC)Tg, B6-Kras KO/KrasPAC Tg
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptionDouble mutant mice having a Kras gene knockout and human KRAS gene transgene.
Colony maintenance
References
K-ras is essential for the development of the mouse embryo.
Koera K, Nakamura K, Nakao K, Miyoshi J, Toyoshima K, Hatta T, Otani H, Aiba A, Katsuki M
Oncogene, 15, 1151-1159 (1997). 9294608

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Kras
MGI:96680		Kirsten rat sarcoma viral oncogene homolog6Kras<tm1Mok>
MGI:1857551		targeted mutation 1, Motoya Katsuki
  • acute myeloid leukemia(MedGEN)

  • arteriovenous malformations of the brain(MedGEN)

  • autoimmune lymphoproliferative syndrome type 4(MedGEN)
    • more 12 Diseases
  • cardiofaciocutaneous syndrome 2(MedGEN)

  • cardiofaciocutaneous syndrome(DisGeNET)

  • exocrine pancreatic carcinoma(MedGEN)

  • gastric cancer(MedGEN)

  • hereditary breast carcinoma(MedGEN)

  • juvenile myelomonocytic leukemia(DisGeNET)

  • linear nevus sebaceous syndrome(MedGEN)

  • lung cancer(MedGEN)

  • Noonan syndrome 3(DisGeNET, MedGEN)

  • Noonan syndrome(DisGeNET)

  • Toriello-Lacassie-Droste syndrome(MedGEN)

  • urinary bladder cancer(MedGEN)
    • neo neomycin resistance gene (E. coli)6
    KRAS v-Ki-ras2 Kirsten rat sacroma viral oncogene homolog (human)UNKRAS

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal fetal cardiomyocyte proliferation(MP:0003567)

  • abnormal heart morphology(MP:0000266)

  • decreased embryo size(MP:0001698)

  • embryonic growth retardation(MP:0003984)

  • hematopoietic system phenotype(MP:0005397)
    • more 6 phenotypes
  • increased neuron apoptosis(MP:0003203)

  • liver/biliary system phenotype(MP:0005370)

  • prenatal lethality, complete penetrance(MP:0011091)

  • small heart(MP:0002188)

  • thin myocardium(MP:0002652)

  • thin ventricular wall(MP:0000280)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli neo, mouse K-ras, human K-ras oncogene genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Oncogene, 15, 1151-1159 (1997).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data