Strain Information | |
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Image | |
BRC No. | RBRC02378 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6.Cg-Nox1<tm1Cyn> |
Former Common name | Nox1 KO mouse, Nox1 knockout mouse |
H-2 Haplotype | |
ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
Background strain | |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Drs. Chihiro Yabe-Nishimura, Kuniharu Matsuno, Kazumi Iwata at Kyoto Prefectual University of Medicine in 2003. |
Strain description | Nox1 deficient mice. Nox1 gene is a member of the NADPH- dependent superoxide producing enzyme family, which is involved in the production of active oxygen in nonphagocytic cells on the intestine epithelium and vascular smooth muscle. |
Colony maintenance | Backcross to C57BL/6 (Heterozygous or Hemizygote x C57BL/6CrSlc) |
References | Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice. Matsuno K, Yamada H, Iwata K, Jin D, Katsuyama M, Matsuki M, Takai S, Yamanishi K, Miyazaki M, Matsubara H, Yabe-Nishimura C Circulation, 112, 2677-2685 (2005) 16246966 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Nox1 | NADPH oxidase 1 | X | Nox1 | targeted mutation 1, Chihiro Yabe-Nishimura | |||
neo | neomycin resistance gene (E. coli) | X | mouse phosphoglycerate kinase promoter (PGK promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 1 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse phosphoglycerate kinase promoter, E. coli neomycin resistance gene, mouse Nox1 genomic DNA |
Research application | Cardiovascular Research Metabolism Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Circulation, 112, 2677-2685 (2005).The BIOLOGICAL RESOURCE should not be utilized for the application of any patent for commercial purposes without an additional agreement with the DEPOSITOR. The RECIPIENT should not distribute the BIOLOGICAL RESOURCE including any progeny, unmodified derivatives, or any derivatives or genetically engineered modification if such derivative or modification is substantially based on and incorporates an essential element of the BIOLOGICAL RESOURCE to any other individual or entity without the DEPOSITOR's written consent. The RECIPIENT should inform results obtained using the BIOLOGICAL RESOURCE and discuss the authorship of the work with the DEPOSITOR prior to publication. |
Depositor | Chihiro YABE (Kyoto Prefectural University of Medicine) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |