Strain Data Sheet

RBRC02370

update : 2024-04-19

Strain Information
Image
BRC No.	RBRC02370
Type	Targeted Mutation
Species	Mus musculus
Strain name	B6.129-Grn<tm1Mni>
Former Common name	Progranulin knock-out mouse, B6;129-Grn<tm1>
H-2 Haplotype
ES Cell line	E14.1 [129P2/OlaHsd]
Background strain	C57BL/6
Appearance	black [a/a B/B C/C]
Strain development	開発者／機関：東京大学大学院農学生命科学研究科獣医生理学教室および東京大学医科学研究科ヒト疾患モデル研究センターとの共同研究により作出開発年：2001年
Strain description	C57BL/6を背景にprogranulin遺伝子を欠損したマウス
Colony maintenance	兄妹交配戻し交配　Background系統名：C57BL/6J（必要に応じて戻し交配も行う）行動の異常がある
References	Behav. Brain Res., 185, 110-118 (2007). 17764761

Health Report
Examination Date / Room / Rack	2024/03/11Room:3-3Rack:D 2023/12/11Room:3-3Rack:D 2023/09/11Room:3-3Rack:D 2023/06/13Room:3-3Rack:D

Gene
Gene info	Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Grngranulin11Grn<tm1Mni>targeted mutation1, Masugi Nishiharaacrogranulin, epithelin, PC cell-derived growth factor, progranulin Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter GHGrowth hormone polyA (Bovine)11GH Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)11neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Gene

Gene info

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

Grngranulin11Grn<tm1Mni>targeted mutation1, Masugi Nishiharaacrogranulin, epithelin, PC cell-derived growth factor, progranulin

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

GHGrowth hormone polyA (Bovine)11GH

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

neoneomycin resistance gene (E. coli)11neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Ordering Information
供与核酸	mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, Bovine growth hormone poly A signal, mouse Grn genomic DNA
Research application	Neurobiology Research
提供条件	条件を付加する。研究成果の公表にあたって寄託者の指定する文献を引用する。Behav. Brain. Res., 185, 110-118 (2007).
Depositor	西原　眞杉（国立大学法人東京大学）
Strain Status	凍結胚凍結精子
Strain Availability	凍結精子より作出したマウスを2~4ヶ月以内に提供可能凍結精子を1ヶ月以内に提供可能
Additional Info.	Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English) Genotyping protocol -PCR- Genetic Background

BRC mice in Publications

Sasaki T, Kuse Y, Nakamura S, Shimazawa M. Progranulin-deficient macrophages cause cardiotoxicity under hypoxic conditions. Biochem Biophys Res Commun 691 149341(2023) 38039836 Noguchi T, Ebina K, Hirao M, Kawase R, Ohama T, Yamashita S, Morimoto T, Koizumi K, Kitaguchi K, Matsuoka H, Kaneshiro S, Yoshikawa H. Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice. Biochem Biophys Res Commun 465(3) 638-43(2015) 26297947 Hafler BP, Klein ZA, Jimmy Zhou Z, Strittmatter SM. Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice. Brain Res 1588 168-74(2014) 25234724 Kawase R, Ohama T, Matsuyama A, Matsuwaki T, Okada T, Yamashita T, Yuasa-Kawase M, Nakaoka H, Nakatani K, Inagaki M, Tsubakio-Yamamoto K, Masuda D, Nakagawa-Toyama Y, Nishida M, Ohmoto Y, Nishihara M, Komuro I, Yamashita S. Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice. Cardiovasc Res 100(1) 125-33(2013) 23847387 Adachi E, Murakoshi M, Shibata T, Shimozawa K, Sakuma H, Kishida C, Gohda T, Suzuki Y. Progranulin deficiency attenuates tubulointerstitial injury in a mouse unilateral ureteral obstruction model. Exp Anim (2024) 38369347 Sasaki T, Kuse Y, Nakamura S, Shimazawa M, Hara H. Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction. FASEB Bioadv 5(10) 395-411(2023) 37810172 Nies SH, Takahashi H, Herber CS, Huttner A, Chase A, Strittmatter SM. Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β. J Biol Chem 297(4) 101159(2021) 34480901 Hosokawa M, Arai T, Masuda-Suzukake M, Kondo H, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H. Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice. J Neuropathol Exp Neurol 74(2) 158-65(2015) 25575133 Kuse Y, Ohuchi K, Nakamura S, Hara H, Shimazawa M. Microglia increases the proliferation of retinal precursor cells during postnatal development. Mol Vis 24 536-545(2018) 30090016 Takahashi H, Bhagwagar S, Nies SH, Ye H, Han X, Chiasseu MT, Wang G, Mackenzie IR, Strittmatter SM. Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase. Nat Commun 15(1) 1434(2024) 38365772 Murakoshi M, Gohda T, Adachi E, Ichikawa S, Hagiwara S, Suzuki Y. Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice. Sci Rep 11(1) 1194(2021) 33441916 Kuse Y, Tsuruma K, Sugitani S, Izawa H, Ohno Y, Shimazawa M, Hara H. Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina. Sci Rep 6 23811(2016) 27030285

BRC mice in Publications

Sasaki T, Kuse Y, Nakamura S, Shimazawa M.
Progranulin-deficient macrophages cause cardiotoxicity under hypoxic conditions.
Biochem Biophys Res Commun 691 149341(2023) 38039836

Noguchi T, Ebina K, Hirao M, Kawase R, Ohama T, Yamashita S, Morimoto T, Koizumi K, Kitaguchi K, Matsuoka H, Kaneshiro S, Yoshikawa H.
Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice.
Biochem Biophys Res Commun 465(3) 638-43(2015) 26297947

Hafler BP, Klein ZA, Jimmy Zhou Z, Strittmatter SM.
Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice.
Brain Res 1588 168-74(2014) 25234724

Kawase R, Ohama T, Matsuyama A, Matsuwaki T, Okada T, Yamashita T, Yuasa-Kawase M, Nakaoka H, Nakatani K, Inagaki M, Tsubakio-Yamamoto K, Masuda D, Nakagawa-Toyama Y, Nishida M, Ohmoto Y, Nishihara M, Komuro I, Yamashita S.
Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice.
Cardiovasc Res 100(1) 125-33(2013) 23847387

Adachi E, Murakoshi M, Shibata T, Shimozawa K, Sakuma H, Kishida C, Gohda T, Suzuki Y.
Progranulin deficiency attenuates tubulointerstitial injury in a mouse unilateral ureteral obstruction model.
Exp Anim (2024) 38369347

Sasaki T, Kuse Y, Nakamura S, Shimazawa M, Hara H.
Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction.
FASEB Bioadv 5(10) 395-411(2023) 37810172

Nies SH, Takahashi H, Herber CS, Huttner A, Chase A, Strittmatter SM.
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
J Biol Chem 297(4) 101159(2021) 34480901

Hosokawa M, Arai T, Masuda-Suzukake M, Kondo H, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H.
Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice.
J Neuropathol Exp Neurol 74(2) 158-65(2015) 25575133

Kuse Y, Ohuchi K, Nakamura S, Hara H, Shimazawa M.
Microglia increases the proliferation of retinal precursor cells during postnatal development.
Mol Vis 24 536-545(2018) 30090016

Takahashi H, Bhagwagar S, Nies SH, Ye H, Han X, Chiasseu MT, Wang G, Mackenzie IR, Strittmatter SM.
Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase.
Nat Commun 15(1) 1434(2024) 38365772

Murakoshi M, Gohda T, Adachi E, Ichikawa S, Hagiwara S, Suzuki Y.
Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice.
Sci Rep 11(1) 1194(2021) 33441916

Kuse Y, Tsuruma K, Sugitani S, Izawa H, Ohno Y, Shimazawa M, Hara H.
Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina.
Sci Rep 6 23811(2016) 27030285

Strain Information

Health Report

Gene

Ordering Information

BRC mice in Publications