Strain Data Sheet
RBRC02345
Strain Information | |
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| Image |  |
| BRC No. | RBRC02345 |
| Type | Transgene |
| Species | Mus musculus |
| Strain name | FVB-Tg(NF2d39)27Gth |
| Former Common name | P0-Nf2delta2-3(#27)tg |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | FVB |
| Appearance | albino [A/A B/B c/c D/D P/P] |
| Strain development | 開発者／機関：INSERM U674開発年：1998年FVB/NにDNA fragmentをmicroinjectionで作成した純粋系統 |
| Strain description | ヒトNf2のミュータント遺伝子をP0 promoter下で発現するtransgenic strain。schwannomasを作るモデルマウス。 |
| Colony maintenance | 戻し交配 Background系統：FVB/N(Charles River) |
| References | Genes Dev., 13, 978-986 (1999) 10215625 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter HBB2rabbit beta-globin polyAUNHBB2 |
Ordering Information | |
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| 供与核酸 | rat P0 promoter, human NF2 cDNAs encoding isoform 1 of Sch-delta(39-121), rabbit beta-globin polyA |
| Research application | Cancer Research Developmental Biology Research Mouse Models for Human Disease Neurobiology Research |
| 提供条件 | 条件を付加する。 研究成果の公表にあたって寄託者の指定する文献を引用する。Genes Dev., 13, 978-986 (1999). 研究成果の公表にあたって謝辞の表明を必要とする。 RECIPIENT shall keep DEPOSITOR apprised of any results obtained from the BIOLOGICAL RESOURCE in the course of the research, as soon as they are available. Moreover, if the research results in a potential invention or a substance that may have potential commercial value (hereinafter referred as to the "Invention") RECIPIENT will promptly disclose this Invention to DEPOSITOR with samples thereof for DEPOSITOR's internal use. RECIPIENT and DEPOSITOR will consult together and agree about the possibility of filing one or more patent application to Invention conceived by one or more employees of Recipients that directly arise out of the research. The Parties will negotiate in good faith the conditions of such patent application according to each party's inventiveness contribution in the Invention. In case of such Invention, patentable or not, reduced in practice or developed in the course of the research that could not have been obtained, reduced to practice or developed but from using the Material and/or Confidential Information, RECIPIENT and DEPOSITOR shall confer with one another as regards licensing and commercialization of such Invention to negotiate in good faith the terms of an institutional agreement as regards said matters. |
| Depositor | Marco Giovannini（INSERM） |
| Strain Status |  凍結胚 |
| Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Truong K, Ahmad I, Jason Clark J, Seline A, Bertroche T, Mostaert B, Van Daele DJ, Hansen MR. Nf2 Mutation in Schwann Cells Delays Functional Neural Recovery Following Injury. Neuroscience 374 205-213(2018) 29408605 |