Strain Data Sheet

RBRC02339

Strain Information

Image
BRC No.RBRC02339
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(Tec-p210 BCR/ABL1)1Homy
Former Common namep210<bcr/abl> Tg
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrlCrlj
Appearanceblack [a/a B/B C/C]
Strain development開発者／機関：本田浩章先生、平井久丸先生／東京大学医学部血液腫瘍内科開発年：1998
Strain descriptionThis transgenic strain expresses the p210 BCR/ABL1 gene. Tg mice show marked granulocyte hyperplasia and develop myeloproliferative disorders closely resembling human chronic myelogenous leukemia.
Colony maintenance戻し交配　Background系統：C57BL/6N（日本チャールズ・リバー）特記：寄託時の戻し交配数は10以上。
ReferencesCancer Sci. 2009 Jul;100(7):1219-26. 19432895
Oncogene. 2008 May 29;27(24):3465-74. 18193087
Blood, 91, 2067-2075 (1998). 9490692
Blood. 2009 May 7;113(19):4702-10. 19234145

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
BCR/ABL1p210 bcr/abl1 (human)UNBCR/ABL1mouse Tec

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
poly ASV40 polyA siganlUNpoly A

Ordering Information

供与核酸mouse Tec genomic DNA, human p210<bcr/abl> cDNA, SV40 virus poly A signal DNA
Research applicationCancer Research
Immunology and Inflammation Research
提供条件条件を付加する。利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。
Depositor本田　浩章（東京女子医科大学）
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

Sánchez-Sánchez B, Gutiérrez-Herrero S, López-Ruano G, Prieto-Bermejo R, Romo-González M, Llanillo M, Pandiella A, Guerrero C, Miguel JF, Sánchez-Guijo F, Del Cañizo C, Hernández-Hernández A.
NADPH oxidases as therapeutic targets in chronic myelogenous leukemia.
Clin Cancer Res 20(15) 4014-25(2014) 24833663