Strain Data Sheet

RBRC02338

Strain Information

Image
BRC No.RBRC02338
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-p130Cas<tm2.1Homy>
Former Common nameCas-FL conditional KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearanceblack [a/a B/B C/C]
Strain development開発者/機関:本田浩章先生/広島大学原爆放射線医科学研究所開発年:2005年特記:寄託時の戻し交配数は3。
Strain descriptionCas<p130> (Crk-associated sucstrate p130)遺伝子のexon2からexon7のゲノムの位置にCas cDNAのcoding領域をloxPで挟んだものと置換してあるfloxマウス(p130Casの完全なconditional knockout mice)
Colony maintenance戻し交配 Background系統:C57BL/6N(日本チャールズ・リバー)
References
Skeletal muscle adaptation in response to mechanical stress in p130cas-/- mice.
Akimoto T, Okuhira K, Aizawa K, Wada S, Honda H, Fukubayashi T, Ushida T
Am. J. Physiol. Cell Physiol., 304(6):C541-7 (2013). 23325412

p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption.
Nagai Y, Osawa K, Fukushima H, Tamura Y, Aoki K, Ohya K, Yasuda H, Hikiji H, Takahashi M, Seta Y, Seo S, Kurokawa M, Kato S, Honda H, Nakamura I, Maki K, Jimi E
J. Bone Miner. Res., 28(12):2449-62 (2013). 23526406

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Bcar1
MGI:108091
breast cancer anti-estrogen resistance 18Bcar1<tm2.1Homy> targeted mutation 2.1, Hiroaki Honda
Frt yeast FRT (flippase recombination target) site8Frt
loxP phage P1 loxP8loxP
loxP phage P1 loxP8loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • muscle phenotype(MP:0005369)
  • Detailed phenotype data

    Ordering Information

    供与核酸phage P1 loxP sites, rat Cas cDNA, SV40 poly A, yeast FRT site, mouse Cas genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    提供条件利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。
    Depositor本田 浩章(東京女子医科大学)
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald LF, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y.
    Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity.
    Sci Adv 5(9) eaau7802(2019) 31579816
    Akimoto T, Okuhira K, Aizawa K, Wada S, Honda H, Fukubayashi T, Ushida T.
    Skeletal muscle adaptation in response to mechanical stress in p130cas-/- mice.
    Am J Physiol Cell Physiol 304(6) C541-7(2013) 23325412