Strain Information | |
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Image | |
BRC No. | RBRC02330 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | NOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk> |
Former Common name | NODFcγRnull |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | albino [A/A c/c] |
Strain development | 開発者/機関:東北大学加齢医学研究所遺伝子導入開発年:2004年J1 EScellを用いて作出し、C57BL/6Nに4-8世代戻し交配を行い、さらにNODに12世代戻し交配を行った。 |
Strain description | IgG抗体受容体であるFCRを欠損させたNODマウスである (文献参照) 。 |
Colony maintenance | 兄妹交配 特記:ホモ×ホモ戻し交配 Background系統名:日本クレアから入手のNOD/shi, jicその他 ホモ×ホモで交配可能 |
References | J. Immunol., 179, 764-774 (2007). 17617565 Cell, 76(3):519-29 (1994). 8313472 Nature, 379, 346-349 (1996). 8552190 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide1Fcer1g<tm1Rav>targeted mutation 1, Jeffrey V RavetchFce1g, FcR-gamma, FcR[g], FcRgamma, Ly-50 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)1neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)1neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
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供与核酸 | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Fcer1g genomic DNA, mouse Fcgr2b genomic DNA |
Research application | Immunology and Inflammation Research |
提供条件 | 条件を付加する。 研究成果の公表にあたって寄託者の指定する文献を引用する。J. Immunol., 179, 764-774 (2007). |
Depositor | 高井 俊行(国立大学法人東北大学) |
Strain Status | 凍結胚 |
Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Kayes T, Fang Y, Yu S, Downey E, Wang S, Braley-Mullen H. Agonistic anti-CD40 induces thyrocyte proliferation and promotes thyroid autoimmunity by increasing CD40 expression on thyroid epithelial cells. J Immunol 190(8) 3928-38(2013) 23509363 Umemoto S, Nakahashi-Ouchida R, Yuki Y, Kurokawa S, Machita T, Uchida Y, Mori H, Yamanoue T, Shibata T, Sawada SI, Ishige K, Hirano T, Fujihashi K, Akiyoshi K, Kurashima Y, Tokuhara D, Ernst PB, Suzuki M, Kiyono H. Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents. NPJ Vaccines 8(1) 106(2023) 37488116 |