Strain Data Sheet

RBRC02314

Strain Information

Image
BRC No.RBRC02314
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Cyp26b1<tm1Hh>
Former Common nameCyp26 b1 null
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb.
Yashiro K, Zhao X, Uehara M, Yamashita K, Nishijima M, Nishino J, Saijoh Y, Sakai Y, Hamada H
Dev. Cell, 6, 411-422 (2004). 15030763

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 16Cyp26b1targeted mutation 1, Hiroshi Hamada
  • lethal occipital encephalocele-skeletal dysplasia syndrome(MedGEN)
  • poly AHSV TK polyA6poly A
  • lethal occipital encephalocele-skeletal dysplasia syndrome(MedGEN)
  • puropuromycin acyltransferase (Streptomyces alboniger)6puromouse phosphoglycerate kinase promoter (PGK promoter)
  • lethal occipital encephalocele-skeletal dysplasia syndrome(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal apoptosis(MP:0001648)

  • abnormal chondrocyte morphology(MP:0000166)

  • abnormal corneocyte envelope morphology(MP:0009594)

  • abnormal epidermal layer morphology(MP:0001216)

  • abnormal epidermis stratum basale morphology(MP:0001231)
  • more 19 phenotypes
  • abnormal epidermis stratum corneum morphology(MP:0001240)

  • abnormal forelimb morphology(MP:0000550)

  • abnormal hair follicle development(MP:0003704)

  • abnormal hindlimb morphology(MP:0000556)

  • abnormal limb bone morphology(MP:0002115)

  • abnormal limb development(MP:0006279)

  • abnormal limb morphology(MP:0002109)

  • abnormal lymphatic vessel endothelial cell morphology(MP:0010197)

  • abnormal proximal-distal axis patterning(MP:0001705)

  • absent keratohyalin granules(MP:0009603)

  • delayed chondrocyte differentiation(MP:0014106)

  • eyelids open at birth(MP:0001302)

  • impaired skin barrier function(MP:0002796)

  • integument phenotype(MP:0010771)

  • micrognathia(MP:0002639)

  • neonatal lethality, complete penetrance(MP:0011087)

  • oligodactyly(MP:0000565)

  • respiratory distress(MP:0001954)

  • short limbs(MP:0000547)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), Streptomyces alboniger puromycin resistance gene, herpes simplex virus thymidine kinase (HSV tk) polyA additional signal, mouse Cyp26b1 genomic DNA
    Research applicationDevelopmental Biology Research
    Metabolism Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Cell, 6, 411-422 (2004).
    DepositorHiroshi Hamada (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data