Information1 | |
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Image | |
BRC No. | RBRC02313 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6;129-Cyp26a1<tm1.1Hmd> Cyp26c1<tm1.1Keya> |
Former Common name | Cyp26 a1c1 null |
H-2 Haplotype | |
ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
Background strain | |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Drs. Masayuki Uehara and Hiroshi Hamada at Oasaka University in 2007. |
Strain description | CYP26A1 and CYP26C1 are retinoic acid-degrading enzymes and thought to play an important role in central nervous system (CNS) development. Homozygous mutant mice in both Cyb26a1 and Cyb26c1 are embryonic lethal, and show anterior-posterior patterning defects in the CNS and impaired production of migratory cranial neural crest cells in the forebrain and midbrain. |
Colony maintenance | Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)Homozygous mutant mice die at embryonic day 11. |
References | Dev. Biol., 302, 399-411 (2007). 17067568 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 119Cyp26a1<tm1.1Hmd>targeted mutation 1.1, Hiroshi HamadaCyp26, MGC:13860, P450RA, P450RAI, RAH, retinoic acid hydrolase Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Cyp26c1cytochrome P450, family 26, subfamily c, polypeptide 119Cyp26c1<tm1.1Keya>targeted mutation 1.1, Kenta YashiroEG546726 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP19loxP |
Information2 | |
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Donor DNA | mouse cyp26al genomic DNA, mouse cyp26cl genomic DNA, phage P1 loxP |
Research application | Developmental Biology Research Metabolism Research Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Biol., 302, 399-411 (2007). |
Depositor | Hiroshi Hamada (RIKEN CDB) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Genotyping protocol -PCR- Necessary documents for ordering: |
BRC mice in Publications |
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