Strain Data Sheet

RBRC02313

Strain Information

Image
BRC No.RBRC02313
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Cyp26a1<tm1.1Hmd> Cyp26c1<tm1.1Keya>
Former Common nameCyp26 a1c1 null
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Masayuki Uehara and Hiroshi Hamada at Oasaka University in 2007.
Strain descriptionCYP26A1 and CYP26C1 are retinoic acid-degrading enzymes and thought to play an important role in central nervous system (CNS) development. Homozygous mutant mice in both Cyb26a1 and Cyb26c1 are embryonic lethal, and show anterior-posterior patterning defects in the CNS and impaired production of migratory cranial neural crest cells in the forebrain and midbrain.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6JJcl)Homozygous mutant mice die at embryonic day 11.
References
CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse.
Uehara M, Yashiro K, Mamiya S, Nishino J, Chambon P, Dolle P, Sakai Y
Dev. Biol., 302, 399-411 (2007). 17067568

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cyp26a1
MGI:1096359		cytochrome P450, family 26, subfamily a, polypeptide 119Cyp26a1<tm1.1Hmd>
MGI:2183292		targeted mutation 1.1, Hiroshi Hamada
Cyp26c1
MGI:2679699		cytochrome P450, family 26, subfamily c, polypeptide 119Cyp26c1<tm1.1Keya>
MGI:3706550		targeted mutation 1.1, Kenta Yashiro
  • focal facial dermal dysplasia type IV(MedGEN)
    • loxP phage P1 loxP19loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal cranial ganglia morphology(MP:0001081)

  • abnormal digestive system development(MP:0003119)

  • abnormal ectomesenchyme morphology(MP:0006302)

  • abnormal facial morphology(MP:0003743)

  • abnormal forebrain development(MP:0003232)
    • more 34 phenotypes
  • abnormal geniculate ganglion morphology(MP:0001082)

  • abnormal head morphology(MP:0000432)

  • abnormal heart morphology(MP:0000266)

  • abnormal hindbrain development(MP:0006108)

  • abnormal hindlimb morphology(MP:0000556)

  • abnormal midbrain development(MP:0003864)

  • abnormal nervous system development(MP:0003861)

  • abnormal nervous system morphology(MP:0003632)

  • abnormal neural crest cell migration(MP:0002950)

  • abnormal neural tube morphology(MP:0002151)

  • abnormal rhombomere morphology(MP:0000933)

  • abnormal somite development(MP:0001688)

  • abnormal tail bud morphology(MP:0002861)

  • abnormal trigeminal ganglion morphology(MP:0001092)

  • absent tail(MP:0003456)

  • absent trigeminal ganglion(MP:0013183)

  • cochlear ganglion hypoplasia(MP:0003637)

  • embryonic lethality during organogenesis, complete penetrance(MP:0011098)

  • exencephaly(MP:0000914)

  • forebrain hypoplasia(MP:0000784)

  • fused kidneys(MP:0003605)

  • incomplete embryo turning(MP:0001701)

  • increased hindbrain size(MP:0012265)

  • kinked tail(MP:0000585)

  • microcephaly(MP:0000433)

  • midbrain hypoplasia(MP:0012090)

  • nervous system phenotype(MP:0003631)

  • open neural tube(MP:0000929)

  • perinatal lethality, complete penetrance(MP:0011089)

  • pharyngeal arch hypoplasia(MP:0003873)

  • short tail(MP:0000592)

  • sirenomelia(MP:0003445)

  • truncated tail bud(MP:0013180)

  • vertebral transformation(MP:0003036)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse cyp26al genomic DNA, mouse cyp26cl genomic DNA, phage P1 loxP
    Research applicationDevelopmental Biology Research
    Metabolism Research
    Neurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Biol., 302, 399-411 (2007).
    DepositorHiroshi Hamada (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data