Strain Data Sheet

RBRC02313

Information1

Image
BRC No.RBRC02313
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Cyp26a1<tm1.1Hmd> Cyp26c1<tm1.1Keya>
Former Common nameCyp26 a1c1 null
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Masayuki Uehara and Hiroshi Hamada at Oasaka University in 2007.
Strain descriptionCYP26A1 and CYP26C1 are retinoic acid-degrading enzymes and thought to play an important role in central nervous system (CNS) development. Homozygous mutant mice in both Cyb26a1 and Cyb26c1 are embryonic lethal, and show anterior-posterior patterning defects in the CNS and impaired production of migratory cranial neural crest cells in the forebrain and midbrain.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6JJcl)Homozygous mutant mice die at embryonic day 11.
ReferencesDev. Biol., 302, 399-411 (2007). 17067568

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 119Cyp26a1<tm1.1Hmd>targeted mutation 1.1, Hiroshi HamadaCyp26, MGC:13860, P450RA, P450RAI, RAH, retinoic acid hydrolase

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Cyp26c1cytochrome P450, family 26, subfamily c, polypeptide 119Cyp26c1<tm1.1Keya>targeted mutation 1.1, Kenta YashiroEG546726

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP19loxP

Information2

Donor DNAmouse cyp26al genomic DNA, mouse cyp26cl genomic DNA, phage P1 loxP
Research applicationDevelopmental Biology Research
Metabolism Research
Neurobiology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Biol., 302, 399-411 (2007).
DepositorHiroshi Hamada (RIKEN CDB)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-
Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data