Strain Information | |
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Image | |
BRC No. | RBRC02313 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129-Cyp26a1<tm1.1Hmd> Cyp26c1<tm1.1Keya> |
Former Common name | Cyp26 a1c1 null |
H-2 Haplotype | |
ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
Background strain | |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Drs. Masayuki Uehara and Hiroshi Hamada at Oasaka University in 2007. |
Strain description | CYP26A1 and CYP26C1 are retinoic acid-degrading enzymes and thought to play an important role in central nervous system (CNS) development. Homozygous mutant mice in both Cyb26a1 and Cyb26c1 are embryonic lethal, and show anterior-posterior patterning defects in the CNS and impaired production of migratory cranial neural crest cells in the forebrain and midbrain. |
Colony maintenance | Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)Homozygous mutant mice die at embryonic day 11. |
References | CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse. Uehara M, Yashiro K, Mamiya S, Nishino J, Chambon P, Dolle P, Sakai Y Dev. Biol., 302, 399-411 (2007). 17067568 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Cyp26a1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | 19 | Cyp26a1 | targeted mutation 1.1, Hiroshi Hamada | |||
Cyp26c1 | cytochrome P450, family 26, subfamily c, polypeptide 1 | 19 | Cyp26c1 | targeted mutation 1.1, Kenta Yashiro | |||
loxP | phage P1 loxP | 19 | loxP |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 34 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse cyp26al genomic DNA, mouse cyp26cl genomic DNA, phage P1 loxP |
Research application | Developmental Biology Research Metabolism Research Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Biol., 302, 399-411 (2007). |
Depositor | Hiroshi Hamada (RIKEN CDB) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |