Strain Data Sheet

RBRC02312

Strain Information

Image
BRC No.RBRC02312
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Cyp26a1<tm1.1Hmd>
Former Common nameCyp26 a1 null
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo.
Sakai Y, Meno C, Fujii H, Nishino J, Shiratori H, Saijoh Y, Rossant J, Hamada H
Genes Dev., 15, 213-225 (2001). 11157777

CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse.
Uehara M, Yashiro K, Mamiya S, Nishino J, Chambon P, Dolle P, Sakai Y
Dev. Biol., 302, 399-411 (2007). 17067568

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cyp26a1
MGI:1096359		cytochrome P450, family 26, subfamily a, polypeptide 119Cyp26a1<tm1.1Hmd>
MGI:2183292		targeted mutation 1.1, Hiroshi Hamada
loxP phage P1 loxP19loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal digestive system development(MP:0003119)

  • abnormal digestive system morphology(MP:0000462)

  • abnormal heart morphology(MP:0000266)

  • abnormal hindbrain development(MP:0006108)

  • abnormal hindlimb morphology(MP:0000556)
    • more 18 phenotypes
  • abnormal kidney morphology(MP:0002135)

  • abnormal nervous system development(MP:0003861)

  • abnormal nervous system morphology(MP:0003632)

  • abnormal neural tube morphology(MP:0002151)

  • abnormal somite development(MP:0001688)

  • abnormal tail bud morphology(MP:0002861)

  • abnormal ureter morphology(MP:0000534)

  • absent tail(MP:0003456)

  • exencephaly(MP:0000914)

  • fused kidneys(MP:0003605)

  • incomplete embryo turning(MP:0001701)

  • kinked tail(MP:0000585)

  • open neural tube(MP:0000929)

  • perinatal lethality, complete penetrance(MP:0011089)

  • prenatal lethality, incomplete penetrance(MP:0011101)

  • short tail(MP:0000592)

  • sirenomelia(MP:0003445)

  • vertebral transformation(MP:0003036)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP site, mouse Cyp26a1 genomic DNA
    Research applicationCre/loxP system
    Developmental Biology Research
    Metabolism Research
    Neurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev., 15, 213-225 (2001). Dev. Biol., 302, 399-411 (2007).
    DepositorHiroshi Hamada (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data