Strain Information | |
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Image | |
BRC No. | RBRC02312 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129-Cyp26a1<tm1.1Hmd> |
Former Common name | Cyp26 a1 null |
H-2 Haplotype | |
ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
Background strain | |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Sakai Y, Meno C, Fujii H, Nishino J, Shiratori H, Saijoh Y, Rossant J, Hamada H Genes Dev., 15, 213-225 (2001). 11157777CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse. Uehara M, Yashiro K, Mamiya S, Nishino J, Chambon P, Dolle P, Sakai Y Dev. Biol., 302, 399-411 (2007). 17067568 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Cyp26a1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | 19 | Cyp26a1 | targeted mutation 1.1, Hiroshi Hamada | |||
loxP | phage P1 loxP | 19 | loxP |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 18 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | phage P1 loxP site, mouse Cyp26a1 genomic DNA |
Research application | Cre/loxP system Developmental Biology Research Metabolism Research Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev., 15, 213-225 (2001). Dev. Biol., 302, 399-411 (2007). |
Depositor | Hiroshi Hamada (RIKEN CDB) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |