Strain Data Sheet

RBRC02292

Strain Information

Image
BRC No.RBRC02292
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S2-Gcnt2<tm1Tmu>
Former Common nameIGnT-KO /C57BL/6J
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
A novel variant form of murine beta-1, 6-N-acetylglucosaminyltransferase forming branches in poly-N-acetyllactosamines.
G Y Chen, N Kurosawa, T Muramatsu
Glycobiology, 10, 1001-1011 (2000). 11030746

Abnormalities caused by carbohydrate alterations in Ibeta6-N-acetylglucosaminyltransferase-deficient mice.
Guo-Yun Chen, Hisako Muramatsu, Mineo Kondo, Nobuyuki Kurosawa, Yozo Miyake, Naoki Takeda, Takashi Muramatsu
Mol. Cell. Biol., 25, 7828-7838 (2005). 16107727

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Gcnt2
MGI:1100870		glucosaminyl (N-acetyl) transferase 2 (I blood group)13Gcnt2<tm1Tmu>
MGI:3589370		targeted mutation 1, Takashi Muramatsu
  • cataract 13 with adult I phenotype(MedGEN)
    • neo neomycin resistance gene (E. coli)13 polyoma virus thymidine kinase gene promoter (tk promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal renal tubule epithelium morphology (MP:0009640)

  • decreased B cell number (MP:0005017)

  • decreased locomotor activity (MP:0001402)

  • epithelioid cyst (MP:0002015)

  • increased blood urea nitrogen level (MP:0005565)
    • more 1 phenotypes
  • increased circulating creatinine level (MP:0005553)
    • Detailed phenotype data

    Ordering Information

    Donor DNApolyoma virus thymidine kinase gene promoter (tk promoter), E. coli Neo, mouse Gcnt2 genomic DNA
    Research applicationImmunology and Inflammation Research
    Internal/Organ Research
    Metabolism Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell. Biol., 25, 7858-7838 (2005). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR (Dr. Hisako Muramatsu) is requested.
    DepositorHisako Muramatsu (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data