Strain Data Sheet

RBRC02289

Strain Information

Image
BRC No.RBRC02289
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S4-Cckbr<tm1Tom>
Former Common nameCCKBR knock-out mice
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo.
Nagata A, Ito M, Iwata N, Kuno J, Takano H, Minowa O, Chihara K, Matsui T, Noda T
Proc. Natl. Acad. Sci. USA, 93, 11825-11830 (1996). 8876222

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cckbrcholecystokinin B receptor7Cckbrtargeted mutation 1, Toshimitsu Matsui
lacZbeta-galactosidase (E. coli)7
neoneomycin resistance gene (E. coli)7mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal behavior(MP:0004924)

  • abnormal blood circulation(MP:0002128)

  • abnormal circulating iron level(MP:0004152)

  • abnormal digestive system physiology(MP:0001663)

  • abnormal eating behavior(MP:0001431)
  • more 26 phenotypes
  • abnormal excitatory postsynaptic currents(MP:0002910)

  • abnormal nociception after inflammation(MP:0002736)

  • abnormal physiological response to xenobiotic(MP:0008872)

  • abnormal stomach mucosa morphology(MP:0010792)

  • decreased anxiety-related response(MP:0001364)

  • decreased body weight(MP:0001262)

  • decreased circulating ferritin level(MP:0011891)

  • decreased circulating unsaturated transferrin level(MP:0011897)

  • decreased grooming behavior(MP:0001442)

  • decreased susceptibility to endotoxin shock(MP:0008734)

  • enhanced behavioral response to addictive substance(MP:0009749)

  • enhanced behavioral response to morphine(MP:0009753)

  • homeostasis/metabolism phenotype(MP:0005376)

  • hyperactivity(MP:0001399)

  • hyporesponsive to tactile stimuli(MP:0005498)

  • impaired behavioral response to cocaine(MP:0009758)

  • impaired coordination(MP:0001405)

  • impaired febrile response(MP:0003829)

  • impaired gastric peristalsis(MP:0009854)

  • increased anxiety-related response(MP:0001363)

  • increased circulating gastrin level(MP:0004731)

  • increased energy expenditure(MP:0004889)

  • increased fluid intake(MP:0011941)

  • increased food intake(MP:0011939)

  • increased liver iron level(MP:0008807)

  • small stomach(MP:0002691)
  • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli lacZ, mouse phosphoglycerate kinase promoter (PGK promoter), E.coli neo, mouse Cckbr genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Internal/Organ Research
    Metabolism Research
    Neurobiology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 93, 11825-11830 (1996). The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use or publication with the results from the use of the BIOLOGICAL RESOURCE. However, it may not be a collaboration if the research interest is out of field of the DEPOSITOR.
    DepositorToshimitsu Matsui (Kobe University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data