Strain Data Sheet

RBRC02287

Strain Information

Image
BRC No.RBRC02287
TypeTargeted Mutation and TransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-St3gal4<tm1.2Bsi> Tg(CAG-flp)1Bsi
Former Common nameST34(#9 CAGflep)C57BL/6J, #9 CAGflep
H-2 Haplotype
ES Cell lineMS12 [C57BL/6]
Background strainC57BL/6JJcl
Appearance
Strain development2004年、平林義雄先生、RIKEN BSI
Strain descriptionST3GAL IV conditional targeted mouseの受精卵にCAG-FLP plasmidをtransfectしたもので、ST34GAL targeted配列からneo遺伝子が除かれたマウス。
Colony maintenance繁殖効率A
References
Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.
Paitoon Srimontri, Shogo Endo, Toshiro Sakamoto, Yoshiaki Nakayama, Akira Kurosaka, Shigeyoshi Itohara, Yoshio Hirabayashi, Keiko Kato
J. Neurochem., 131(5):675-87 (2014). 25066807

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site9Frt
St3gal4
MGI:1316743		ST3 beta-galactoside alpha-2,3-sialyltransferase 49St3gal4<tm1.2Bsi>
MGI:5695541		targeted mutation 1.2, RIKEN BSI
loxP phage P1 loxP9loxP
loxP phage P1 loxP9loxP
FLP yeast flippase recombinaseUNFLP CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal conditioned emotional response (MP:0002806)

  • abnormal insulin-like growth factor I level (MP:0008831)

  • abnormal sleep pattern (MP:0001501)

  • behavioral despair (MP:0002573)

  • decreased frequency of paradoxical sleep (MP:0012286)
    • more 5 phenotypes
  • decreased growth hormone level (MP:0005136)

  • decreased kindling response (MP:0001500)

  • increased anxiety-related response (MP:0001363)

  • increased coping response (MP:0003063)

  • increased fear-related response (MP:0003459)
    • Detailed phenotype data

    Ordering Information

    供与核酸マウス ST3Gal IV(欠損), CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), 酵母 FLP組換え酵素遺伝子, 酵母 FRT, P1 ファージ loxP
    Research applicationCre/loxP system
    FLP/frt system
    Metabolism Research
    Mouse Models for Human Disease
    提供条件条件を付加しない。
    Depositor平林　義雄（独立行政法人理化学研究所）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability受注後、検査を施して提供
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. CAGGS MTA (English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data