Strain Data Sheet

RBRC02287

Strain Information

Image
BRC No.RBRC02287
TypeTargeted Mutation and TransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-St3gal4<tm1.2Bsi> Tg(CAG-flp)1Bsi
Former Common nameST34(#9 CAGflep)C57BL/6J, #9 CAGflep
H-2 Haplotype
ES Cell lineMS12 [C57BL/6]
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.
Paitoon Srimontri, Shogo Endo, Toshiro Sakamoto, Yoshiaki Nakayama, Akira Kurosaka, Shigeyoshi Itohara, Yoshio Hirabayashi, Keiko Kato
J. Neurochem., 131(5):675-87 (2014). 25066807

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site9Frt
St3gal4
MGI:1316743		ST3 beta-galactoside alpha-2,3-sialyltransferase 49St3gal4<tm1.2Bsi> targeted mutation 1.2, RIKEN BSI
loxP phage P1 loxP9loxP
loxP phage P1 loxP9loxP
FLP yeast flippase recombinaseUNFLP CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal conditioned emotional response (MP:0002806)

  • abnormal insulin-like growth factor I level (MP:0008831)

  • abnormal sleep pattern (MP:0001501)

  • behavioral despair (MP:0002573)

  • decreased frequency of paradoxical sleep (MP:0012286)
    • more 5 phenotypes
  • decreased growth hormone level (MP:0005136)

  • decreased kindling response (MP:0001500)

  • increased anxiety-related response (MP:0001363)

  • increased coping response (MP:0003063)

  • increased fear-related response (MP:0003459)
    • Detailed phenotype data

    Ordering Information

    Donor DNAマウス ST3Gal IV(欠損), CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), 酵母 FLP組換え酵素遺伝子, 酵母 FRT, P1 ファージ loxP
    Research applicationCre/loxP system
    FLP/frt system
    Metabolism Research
    Mouse Models for Human Disease
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorYoshio Hirabayashi (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. CAGGS MTA (English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data