Strain Data Sheet

RBRC02285

Strain Information

Image
BRC No.RBRC02285
TypeTargeted Mutation and TransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-St3gal4<tm1.1Bsi>
Former Common nameST34(#9 CAGCre)C57BL/6J:913 line, 913; C57BL/6-St3gal4<tm1.1Bsi> Tg(CAG-cre)913Bsi
H-2 Haplotype
ES Cell lineMS12 [C57BL/6]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain development2004年、平林義雄先生、RIKEN BSI
Strain descriptionST3GAL IV conditional targeted mouseの受精卵にCAG-Cre plasmidをtransfectしたもので、ST34GAL IV遺伝子の全身KOマウス。
Colony maintenance繁殖効率C行動の異常がある繁殖成績が低いホモで不妊／死亡
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
St3gal4
MGI:1316743		ST3 beta-galactoside alpha-2,3-sialyltransferase 49St3gal4<tm1.1Bsi> targeted mutation 1.1, RIKEN BSI
loxP phage P1 loxP9loxP

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal conditioned emotional response (MP:0002806)

  • abnormal insulin-like growth factor I level (MP:0008831)

  • abnormal sleep pattern (MP:0001501)

  • behavioral despair (MP:0002573)

  • decreased frequency of paradoxical sleep (MP:0012286)
    • more 5 phenotypes
  • decreased growth hormone level (MP:0005136)

  • decreased kindling response (MP:0001500)

  • increased anxiety-related response (MP:0001363)

  • increased coping response (MP:0003063)

  • increased fear-related response (MP:0003459)
    • Detailed phenotype data

    Ordering Information

    供与核酸mouse ST3Gal IV genomic DNA, phage P1 loxP, CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
    Research applicationMetabolism Research
    Mouse Models for Human Disease
    提供条件条件を付加しない。
    Depositor平林　義雄（独立行政法人理化学研究所）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. CAGGS MTA (English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Fujita A, Okuno T, Oda M, Kato K.
    Urinary volatilome analysis in a mouse model of anxiety and depression.
    PLoS One 15(2) e0229269(2020) 32084196
    Kato K.
    Differential effects of dietary oils on emotional and cognitive behaviors.
    PLoS One 10(3) e0120753(2015) 25799588
    Srimontri P, Endo S, Sakamoto T, Nakayama Y, Kurosaka A, Itohara S, Hirabayashi Y, Kato K.
    Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.
    J Neurochem 131(5) 675-87(2014) 25066807