Strain Data Sheet

RBRC02248

update : 2026-04-20

Strain Information
Image
BRC No.	RBRC02248
Type	Targeted Mutation
Species	Mus musculus
Strain name	B6.Cg-Pcdha<tm(dupSR2/Neo)>/TyagRbrc
Former Common name	CNRSR2dupli+Neo, CNR SR2dupli+Neo
H-2 Haplotype
ES Cell line	TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development	Developed by Takeshi Yagi, Graduate School of Frontier Biosciences, Osaka University in 2007. TT2 ES cells were used to generate the mutant mice.
Strain description	The region of SR2 of the CNR (Pcdha) gene was duplicated.
Colony maintenance	Homozygote x Homozygote [or Crossing to C57BL/6J(Crlj)]
References

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
Frt	yeast FRT (flippase recombination target) site	18	Frt
Pcdha MGI:3719085	protocadherin alpha cluster	18	Pcdha<tm(dupSR2/Neo)>	targeted mutation
loxP	phage P1 loxP	18	loxP
neo	neomycin resistance gene (E. coli)	18

Phenotype
Phenotype annotation from literatures by Mammalian phenotype ontology
Detailed phenotype data

Ordering Information
Donor DNA	Phage P1loxP， yeast FRT、E. coli neo
Research application	Cre/loxP system FLP/frt system Neurobiology Research
Specific Term and Conditions	The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. If the RECIPIENT's research results in an invention based on the BOLOGICAL RESOURCE, the RECIPIENT must contact DEPOSITOR to negotiate. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, the RECIPIENT must obtain a prior written consent from the DEPOSITOR.
Depositor	Takeshi Yagi (Osaka University)
Strain Status	Frozen embryos
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month)
Additional Info.	Necessary documents for ordering: Approval form (Japanese / English) Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English) Lab HP (Japanese)

BRC mice in Publications

No Data