Strain Data Sheet

RBRC02244

Strain Information

Image
BRC No.RBRC02244
TypeTargeted Mutation and Spontaneous MutationCartagena
SpeciesMus musculus
Strain nameSTOCK Pcdha<tm3Tyag> Mbp<shi>/TyagRbrc
Former Common nameBBS(Pcdha BdAB homo/shiverer hetero , BBSS(Pcdha BdAB homo/shiverer homo), CNR BdAB/Shiverer
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain developmentDeveloped by Takeshi Yagi, Graduate School of Frontier Biosciences, Osaka University in 2006. Mixed background.
Strain descriptionCNR (Pcdha) delta CR (RBRC01688) and shiverer double mutant mice. shiverer homozygous mutant mice show tremor and die around 4 months of age.
Colony maintenancePcdha: Homozygote x Homozygote; shi: Heterozygote x Wild-type
References
Shiverer: an autosomal recessive mutant mouse with myelin deficiency.
G F Chernoff
J. Hered., 72, 128 (1981) 6168677

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mbp
MGI:96925		myelin basic protein18Mbp<shi>
MGI:1856159		shiverer
Pcdha
MGI:3719085		protocadherin alpha cluster18Pcdha<tm3Tyag>
MGI:3797610		targeted mutation 3, Takeshi Yagi
loxP phage P1 loxP18loxP

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal axonal transport (MP:0004768)

  • abnormal cingulate gyrus morphology (MP:0004167)

  • abnormal dentate gyrus morphology (MP:0000812)

  • abnormal dorsal striatum morphology (MP:0004102)

  • abnormal entorhinal cortex morphology (MP:0006300)
    • more 38 phenotypes
  • abnormal globus pallidus morphology (MP:0004081)

  • abnormal hippocampus morphology (MP:0000807)

  • abnormal lateral geniculate nucleus morphology (MP:0004165)

  • abnormal maternal nurturing (MP:0001386)

  • abnormal myelin sheath morphology (MP:0003871)

  • abnormal myelination (MP:0000920)

  • abnormal neuron morphology (MP:0002882)

  • abnormal olfactory bulb morphology (MP:0000819)

  • abnormal primary motor cortex morphology (MP:0012448)

  • abnormal serotonergic neuron morphology (MP:0003877)

  • abnormal spatial learning (MP:0001463)

  • abnormal substantia nigra morphology (MP:0000836)

  • abnormal thalamus morphology (MP:0000832)

  • absent linear vestibular evoked potential (MP:0004813)

  • ataxia (MP:0001393)

  • audiogenic seizures (MP:0001496)

  • decreased body weight (MP:0001262)

  • decreased brain cholesterol level (MP:0010161)

  • decreased cholesterol level (MP:0003983)

  • decreased nerve conduction velocity (MP:0008814)

  • decreased susceptibility to Picornaviridae infection (MP:0020938)

  • environmentally induced seizures (MP:0009358)

  • hindlimb paralysis (MP:0000755)

  • impaired coordination (MP:0001405)

  • increased T cell proliferation (MP:0005348)

  • increased grooming behavior (MP:0001441)

  • increased interferon-gamma secretion (MP:0008566)

  • increased interleukin-2 secretion (MP:0008687)

  • increased interleukin-4 secretion (MP:0008699)

  • increased serotonin level (MP:0010069)

  • increased susceptibility to experimental autoimmune encephalomyelitis (MP:0004799)

  • limb grasping (MP:0001513)

  • nervous system phenotype (MP:0003631)

  • premature death (MP:0002083)

  • reduced linear vestibular evoked potential (MP:0004814)

  • skin lesions (MP:0001212)

  • tonic seizures (MP:0002826)

  • tremors (MP:0000745)
    • Detailed phenotype data

    Ordering Information

    Donor DNAファージ由来loxP配列
    Research applicationCre/loxP system
    Neurobiology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. If the RECIPIENT's research results in an invention based on the BOLOGICAL RESOURCE, the RECIPIENT must contact DEPOSITOR to negotiate. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, the RECIPIENT must obtain a prior written consent from the DEPOSITOR.
    DepositorTakeshi Yagi (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)

    BRC mice in Publications

    No Data