Strain Information | |
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Image | |
BRC No. | RBRC02240 |
Type | Targeted Mutation and Transgene |
Species | Mus musculus |
Strain name | STOCK Grid2<tm1Mim> Tg(Pcp2-Grid2*R514K)1Yuza |
Former Common name | GluRδ2 rescue line-R/K |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | In 2001, transgenic mice (Tg(PCP2-Grid2R/K)) lines were established by injection into fertilized FVB/N mouse eggs by the donating investigator at St. Jude Children’s Hospital.In 2002, the transgenic mice were bred on GluRδ2-/- background by crossing with B6-Grid2tm3Mish lines (RIKEN BRC No.01657). |
Strain description | The transgene (Grid2R/K), which has a mutation in the putative ligand binding site of the δ2 glutamate receptor, is expressed specifically in cerebellar Purkinje cells by a PCP2 promoter. |
Colony maintenance | 繁殖効率:AThe mice are supplied as homozygotes for the transgene (Tg(PCP2-Grid2R/K)) on GluRδ2-/- background. Therefore, when crossed within a colony, no genotypings are necessary. |
References | EMBO reports, 6, 90-95 (2005). 15592450 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Grid2glutamate receptor, ionotropic, delta 26Grid2<tm1Mim>targeted mutation 1, Masayoshi MishinaB230104L07Rik, GluRdelta2, tpr Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)6neo; neomycin; Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter |
Ordering Information | |
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供与核酸 | mouse PCP2 promoter, mouse Grid2 cDNA |
Research application | Neurobiology Research |
提供条件 | 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。 GluRd2KOマウスの使用に際しては、GluRδ2KO mouse(BRC No.01657)の下記の寄託条件の範囲内で利用する。「寄託者の提供承諾書を得る。研究成果の公表にあたって謝辞の表明を必要とする。利用者が本リソースを用いて得た成果に基づき特許、知的所有権、または他の権利を申請する場合には、寄託者の同意を必要とする。本リソースの使用は共同研究のみに限定する。寄託後2年以内の論文発表あるいは寄託後2年以内に論文発表が無い場合はその後の論文発表の際には、利用者は寄託者を共著者とする必要がある。」 |
Depositor | 柚﨑 通介(慶應義塾大学) |
Strain Status | 凍結胚 |
Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |