Strain Information | |
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Image | |
BRC No. | RBRC02230 |
Type | Transgene Congenic |
Species | Mus musculus |
Strain name | B6.Cg-Tg(CAG-Ggt1) |
Former Common name | GGT Tg, C57BL/6Cr |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosis. Hiramatsu K, Asaba Y, Takeshita S, Nimura Y, Tatsumi S, Katagiri N, Niida S, Nakajima T, Tanaka S, Ito M, Karsenty G, Ikeda K Endocrinology, 148, 2708-2715, (2007) 17363454Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor. Niida S, Kawahara M, Ishizuka Y, Ikeda Y, Kondo T, Hibi T, Suzuki Y, Ikeda K, Taniguchi N J. Biol. Chem., 279, 5752-5756 (2004). 14634009 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Ggt1 | gamma-glutamyltransferase 1 | UN | Ggt1 | CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA) | |||
HBB2 | rabbit beta-globin polyA | UN | HBB2 | ||||
loxP | phage P1 loxP | UN | loxP |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), mouse GGT(γ-glutamyltransferase cDNA)chicken beta-actin promoter, P1 Phage loxP) |
Research application | Metabolism Research Mouse Models for Human Disease |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Endocrinology, 148(6):2708-2715 (2007).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Kyoji Ikeda (National Center for Geriatrics and Gerontology) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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