Strain Data Sheet

RBRC02194

Strain Information

Image
BRC No.RBRC02194
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(hCD2-CA-AhR)K
Former Common nameT-cell-specific CA-AhR Tg, Line K
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes.
Nohara K, Pan X, Tsukumo S, Hida A, Ito T, Nagai H, Inouye K, Motohashi H, Yamamoto M, Fujii-Kuriyama Y, Tohyama C
J. Immunol. 174, 2770-2777 (2005). 15728486

Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus involution independently of the Fas/Fas ligand signaling pathway.
Nagai H, Kubo M, Abe R, Yamamoto M, Nohara K
Int. Immunopharmacol. 6, 279-286 (2006). 16399633

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
CA-AhRconstitutively active aryl-hydrocarbon receptor (AhR)UNCA-AhRhuman CD2 promoter
  • retinitis pigmentosa 85(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • thymus atrophy(MP:0003644)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Arylhydrocarbon receptor (PAS B deletion mutant), human CD2 Promoter (5kb promeoter, 5.5 kb LCR), human K14 polyA
    Research applicationApoptosis Research
    Cell Biology Research
    Immunology and Inflammation Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to include the DEPOSITOR as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE. The RECIPIENT should contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
    DepositorKeiko Nohara (National Institute for Environmental Studies)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)

    BRC mice in Publications

    No Data