Strain Information | |
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Image | |
BRC No. | RBRC02095 |
Type | Transgene Congenic |
Species | Mus musculus |
Strain name | B6.B6D2-Tg(Th-EGFP)21-31Koba |
Former Common name | B6.Cg-Tg(TH-GFP)21-31 |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C] |
Strain development | 福島県立医科大学医学部・小林和人先生(1998)。B6D2F2受精卵へインジェクションにより作出。C57BL/6Jに戻し交配された。2ラインあり。RBRC02095(メインライン)、RBRC03162。 |
Strain description | ラットチロシン水酸化酵素 (TH) 遺伝子プロモーターに、オワンクラゲ緑色蛍光タンパク質 (GFP) 遺伝子を接続した導入遺伝子を持つ。Tgマウスは脳内および末梢器官のカテコールアミン合成細胞がGFPにより標識される。ホモマウスは致死 (原因は不明) 。 |
Colony maintenance | Carrier x Noncarrier [C57BL/6JJcl] |
References | J. Neurochem., 82, 295-304 (2002). 12124430 |
Health Report | |
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Examination Date / Room / Rack | 2024/02/19Room:4-ARack:K 2023/11/20Room:4-ARack:K 2023/08/21Room:4-ARack:K 2023/05/22Room:4-ARack:K 2023/02/20Room:4-ARack:K 2022/11/21Room:4-ARack:K 2022/08/22Room:4-ARack:K 2022/05/23Room:4-ARack:K |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter GFPGreen Fluorescent Protein (Aequorea victoria)UNrat tyrosine hydroxylase (TH) promoter |
Ordering Information | |
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供与核酸 | rat tyrosine hydroxylase (TH) promoter, rabbit beta-globin intron, jelly fish green fluorescent protein (GFP) gene, rabbit beta-globin poly A, SV40 early gene poly A |
Research application | Fluorescent Proteins/lacZ System Neurobiology Research |
提供条件 | 条件を付加する。 研究成果の公表にあたって寄託者の指定する文献を引用する。J. Neurochem., 82, 295-304 (2002). |
Depositor | 小林 和人(公立大学法人福島県立医科大学) |
Strain Status | 生体 凍結胚 凍結精子 |
Strain Availability | 凍結精子を1ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 生体マウスを1~3ヶ月以内に提供可能 |
Additional Info. | Construct map Transgene sequence Mouse of the Month May 2008 Genetic Background Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Heo JY, Nam MH, Yoon HH, Kim J, Hwang YJ, Won W, Woo DH, Lee JA, Park HJ, Jo S, Lee MJ, Kim S, Shim JE, Jang DP, Kim KI, Huh SH, Jeong JY, Kowall NW, Lee J, Im H, Park JH, Jang BK, Park KD, Lee HJ, Shin H, Cho IJ, Hwang EM, Kim Y, Kim HY, Oh SJ, Lee SE, Paek SH, Yoon JH, Jin BK, Kweon GR, Shim I, Hwang O, Ryu H, Jeon SR, Lee CJ. Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease. Curr Biol 30(2) 276-291.e9(2020) 31928877 Masi A, Narducci R, Resta F, Carbone C, Kobayashi K, Mannaioni G. Differential contribution of Ih to the integration of excitatory synaptic inputs in substantia nigra pars compacta and ventral tegmental area dopaminergic neurons. Eur J Neurosci 42(9) 2699-706(2015) 26354486 Kiyokage E, Kobayashi K, Toida K. Spatial distribution of synapses on tyrosine hydroxylase-expressing juxtaglomerular cells in the mouse olfactory glomerulus. J Comp Neurol 525(5) 1059-1074(2017) 27864931 Suzuki Y, Kiyokage E, Sohn J, Hioki H, Toida K. Structural basis for serotonergic regulation of neural circuits in the mouse olfactory bulb. J Comp Neurol 523(2) 262-80(2015) 25234191 Sawada M, Kaneko N, Inada H, Wake H, Kato Y, Yanagawa Y, Kobayashi K, Nemoto T, Nabekura J, Sawamoto K. Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb. J Neurosci 31(32) 11587-96(2011) 21832189 Zhu S, Zhao C, Wu Y, Yang Q, Shao A, Wang T, Wu J, Yin Y, Li Y, Hou J, Zhang X, Zhou G, Gu X, Wang X, Bustelo XR, Zhou J. Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. Nat Neurosci 18(8) 1084-93(2015) 26147533 Kosaka T, Pignatelli A, Kosaka K. Heterogeneity of tyrosine hydroxylase expressing neurons in the main olfactory bulb of the mouse. Neurosci Res 157 15-33(2020) 31629793 |