Strain Data Sheet

RBRC01948

Strain Information

Image
BRC No.RBRC01948
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameICR.Cg-Mesp2<tm13(cre/Esr1*)Ysa>/Rbrc
Former Common nameP2MCM; P2MCM knock-in mouse; P2neoMCM knock-in
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation.
Yu Takahashi, Yukuto Yasuhiko, Satoshi Kitajima, Jun Kanno, Yumiko Saga
Dev Biol., 304, 593-603 (2007). 17306789

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Esr1* estrogen receptor 1 (alpha), mouse ER with a mutation G525R)7Esr1*
Frt yeast FRT (flippase recombination target) site7Frt
Frt yeast FRT (flippase recombination target) site7Frt
Mesp2
MGI:1096325		mesoderm posterior 27Mesp2<tm13(cre/Esr1*)Ysa>
MGI:3715268		targeted mutation 13, Yumiko Saga
  • spondylocostal dysostosis 1, autosomal recessive(MedGEN)

  • spondylocostal dysostosis 2, autosomal recessive(MedGEN)
    • cre Phage P1 Cre recombinase7cre
    neo neomycin resistance gene (E. coli)7 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal somite development (MP:0001688)

  • abnormal vertebrae morphology (MP:0000137)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmutant-type mouse estrogen receptor (Mer) cDNA, Phage P1 Cre recombinase, yeast FRT (flippase recombination target) sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, polyA, mouse Mesp2 genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Cre driver
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Biol., 304, 593-603 (2007).
    DepositorJun Kanno (National Institute of Health Sciences)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data