Strain Information | |
---|---|
Image | |
BRC No. | RBRC01948 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | ICR.Cg-Mesp2<tm13(cre/Esr1*)Ysa>/Rbrc |
Former Common name | P2MCM; P2MCM knock-in mouse; P2neoMCM knock-in |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation. Takahashi Y, Yasuhiko Y, Kitajima S, Kanno J, Saga Y Dev Biol., 304, 593-603 (2007). 17306789 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |||||||
---|---|---|---|---|---|---|---|
Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Esr1* | estrogen receptor 1 (alpha), mouse ER with a mutation G525R) | 7 | Esr1* | ||||
Frt | yeast FRT (flippase recombination target) site | 7 | Frt | ||||
Frt | yeast FRT (flippase recombination target) site | 7 | Frt | ||||
Mesp2 | mesoderm posterior 2 | 7 | Mesp2 | targeted mutation 13, Yumiko Saga | |||
cre | Phage P1 Cre recombinase | 7 | cre | ||||
neo | neomycin resistance gene (E. coli) | 7 | mouse phosphoglycerate kinase promoter (PGK promoter) |
Phenotype | |
---|---|
Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
---|---|
Donor DNA | mutant-type mouse estrogen receptor (Mer) cDNA, Phage P1 Cre recombinase, yeast FRT (flippase recombination target) sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, polyA, mouse Mesp2 genomic DNA |
Research application | Cre/loxP system FLP/frt system |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Biol., 304, 593-603 (2007). |
Depositor | Jun Kanno (National Institute of Health Sciences) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
---|
No Data |