Strain Data Sheet

RBRC01942

Strain Information

Image
BRC No.RBRC01942
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S2-Creb3l4<tm1Noj>
Former Common nameTisp40 KO mouse
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strain
Appearanceblack [a/a B/B C/C]
Strain development大阪大学微生物病研究所・薮田紀一先生、野島　博先生（2004）。D3 ES細胞を用いて作出。C57BL/6へ戻し交配（N6以上）。
Strain descriptionTISP40 (Creb3l4) 遺伝子のノックアウトマウス。エクソン5から10をneoカセットで置換。TISP40はマウス精子形成過程に特異的に転写誘導される遺伝子であり、Histone置換への関与が示唆されている。生体内におけるTISP40遺伝子の機能解析に有用。ホモマウスは繁殖性、妊性あり。
Colony maintenanceHeterozygote x Homozygote [or Crossing to C57BL/6NCrSlc]
References
The testes-specific bZip type transcription factor Tisp40 plays a role in ER stress responses and chromatin packaging during spermiogenesis.
Ippei Nagamori, Kentaro Yomogida, Masahito Ikawa, Masaru Okabe, Norikazu Yabuta, Hiroshi Nojima
Genes Cells, 11, 1161-1171 (2006). 16999736

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Creb3l4
MGI:1916603		cAMP responsive element binding protein 3-like 43Creb3l4<tm1Noj>
MGI:3718553		targeted mutation 1, Hiroshi Nojima
neo neomycin resistance gene (E. coli)3 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal spermatid morphology (MP:0006380)

  • decreased male germ cell number (MP:0004901)
    • Detailed phenotype data

    Ordering Information

    供与核酸mouse Creb3l4 genomic DNA, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo
    Research applicationCell Biology Research
    Reproductive Biology Research
    提供条件利用者は事前に寄託者の提供承諾書を得る。研究成果の公表にあたって寄託者の指定する文献を引用する。Genes to Cells, 11, 1161-1171 (2006). 共同研究
    Depositor野島　博（国立大学法人大阪大学）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Xie J, Wang L, Tian S, Li R, Zhang L, Shi H, Liu Z, Ma T, Hu H, She Z, Wang L.
    The Protective Role of Transcript-Induced in Spermiogenesis 40 in Cerebral Ischemia-Reperfusion Injury.
    Neurochem Res 49(9) 2519-2534(2024) 38884889
    Qin C, Li M, Bai T, Yang K, Xu T, Zhang J.
    Tisp40 deficiency limits renal inflammation and promotes tubular cell proliferation in renal ischemia reperfusion injury.
    Exp Cell Res 371(1) 255-261(2018) 30121191
    Qin C, Xiao C, Su Y, Zheng H, Xu T, Lu J, Luo P, Zhang J.
    Tisp40 deficiency attenuates renal ischemia reperfusion injury induced apoptosis of tubular epithelial cells.
    Exp Cell Res 359(1) 138-144(2017) 28778797