Strain Data Sheet

RBRC01888

update : 2024-04-19

Strain Information
Image
BRC No.	RBRC01888
Type	Spontaneous Mutation Congenic
Species	Mus musculus
Strain name	C57BL/6-W<sh>/W<sh>
Former Common name	W sash, C57BL/6-W<sh>
H-2 Haplotype
ES Cell line
Background strain	C57BL/6J
Appearance	white, black eyes [a/a B/B C/C Sh/Sh] black [a/a B/B C/C +/+] black with white spotting [a/a B/B C/C Sh/+]
Strain development	大阪大学・北村幸彦博士がマスト細胞研究のため1980年代にDr J.F.Loutit (MRC Radiobiology Unit, Harwell, Didcot, UK)より日本に導入し、20世代以上C57BL/6に戻し交配を行い、C57BL/6-W<sh>/+系統として確立された、その後、理化学研究所ライフサイエンス筑波研究センターに導入され、メラノサイトの研究のためにBALB/c系統に4世代戻し交配をしてホモ化された（C;B6-a/a- b/b /W<sh>/W<sh>、RBRC00762）。2004年、理研BRCよりRCAIに導入されたF21世代のマウスを基に、再度C57BL/6系統へ10世代戻し交配が行われた（2006年7月）
Strain description	マスト細胞、メラノサイトの欠損マウス。雌雄とも繁殖可能。黒目で体は白毛。メラノサイトおよび生殖腺におけるc-kitの機能解析。変異の位置や種類は未解析。
Colony maintenance	兄妹交配による維持。繁殖効率：A~Bヘテロは黒色の毛色に白帯の胴体、ホモは白色黒目。交配はW<sh>/W<sh>♂ × W<sh>/+♀またはホモ × ホモで行う。
References	Genet. Res., 39, 315-322 (1982). 7117838 Blood, 83, 3509-3516 (1994). 7515715 Am. J. Pathal., 167, 835-848 (2005). 16127161 Blood, 94, 2658-2666 (1999). 10515869 Blood, 80, 1448-1453 (1992). 1381627 Development, 118, 705-717 (1993). 7521281

Health Report
Examination Date / Room / Rack	2024/03/11Room:3-6Rack:A 2023/12/11Room:3-6Rack:A 2023/09/11Room:3-6Rack:A 2023/07/18Room:3-6Rack:A 2023/06/13Room:3-6Rack:A 2023/03/13Room:3-6Rack:A 2022/12/12Room:3-6Rack:A 2022/09/12Room:3-6Rack:A 2022/06/13Room:3-6Rack:A

Gene
Gene info	Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Kitkit oncogene5Kit<W-Sh>sashbelly-spot, c-KIT, CD117, Dominant white spotting, Steel Factor Receptor, Tr-kit

Ordering Information
供与核酸
Research application	Dermatology Research Immunology and Inflammation Research
提供条件	条件を付加しない。
Depositor	大保木　啓介（独立行政法人理化学研究所）
Strain Status	生体凍結胚凍結精子
Strain Availability	凍結精子を1ヶ月以内に提供可能凍結胚を1ヶ月以内に提供可能生体マウスを1~3ヶ月以内に提供可能
Additional Info.	Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Genotyping protocol -PCR- Genetic Background

BRC mice in Publications

Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T. Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice. Cancer Res 74(11) 3011-9(2014) 24879565 Schuler P, Contassot E, Irla M, Hugues S, Preynat-Seauve O, Beermann F, Donda A, French LE, Huard B. Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells. Cancer Res 68(20) 8410-8(2008) 18922914 Murata A, Hikosaka M, Yoshino M, Zhou L, Hayashi SI. Kit-independent mast cell adhesion mediated by Notch. Int Immunol 31(2) 69-79(2019) 30299470 Hitomi K, Tahara-Hanaoka S, Miki H, Iwata K, Shibayama S, Kubo M, Shibuya A. Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice. Int Immunol 30(9) 429-434(2018) 30169732 Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, Okoshi Y, Nakano-Yokomizo T, Ohkohchi N, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A. Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor. J Exp Med 209(8) 1493-503(2012) 22826299 Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, Yamamoto M. Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice. Mol Cell Biol 34(10) 1812-26(2014) 24615013 Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T. PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. Nat Commun 6 7514(2015) 26159556 Murata T, Aritake K, Matsumoto S, Kamauchi S, Nakagawa T, Hori M, Momotani E, Urade Y, Ozaki H. Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. Proc Natl Acad Sci U S A 108(49) 19802-7(2011) 22106279 Yoshida K, Tanihara S, Miyashita Y, Obayashi K, Ito MA, Yamamoto K, Imai T, Matsuoka I. P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice. Sci Rep 12(1) 18613(2022) 36329102

BRC mice in Publications

Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T.
Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice.
Cancer Res 74(11) 3011-9(2014) 24879565

Schuler P, Contassot E, Irla M, Hugues S, Preynat-Seauve O, Beermann F, Donda A, French LE, Huard B.
Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells.
Cancer Res 68(20) 8410-8(2008) 18922914

Murata A, Hikosaka M, Yoshino M, Zhou L, Hayashi SI.
Kit-independent mast cell adhesion mediated by Notch.
Int Immunol 31(2) 69-79(2019) 30299470

Hitomi K, Tahara-Hanaoka S, Miki H, Iwata K, Shibayama S, Kubo M, Shibuya A.
Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice.
Int Immunol 30(9) 429-434(2018) 30169732

Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, Okoshi Y, Nakano-Yokomizo T, Ohkohchi N, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A.
Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.
J Exp Med 209(8) 1493-503(2012) 22826299

Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, Yamamoto M.
Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice.
Mol Cell Biol 34(10) 1812-26(2014) 24615013

Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T.
PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.
Nat Commun 6 7514(2015) 26159556

Murata T, Aritake K, Matsumoto S, Kamauchi S, Nakagawa T, Hori M, Momotani E, Urade Y, Ozaki H.
Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma.
Proc Natl Acad Sci U S A 108(49) 19802-7(2011) 22106279

Yoshida K, Tanihara S, Miyashita Y, Obayashi K, Ito MA, Yamamoto K, Imai T, Matsuoka I.
P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice.
Sci Rep 12(1) 18613(2022) 36329102

Strain Information

Health Report

Gene

Ordering Information

BRC mice in Publications